PDF(Pubmed)
Abstract：
UNASSIGNED: To describe the role of iron deficiency in both heart failure and pulmonary hypertension.
UNASSIGNED: To role of iron deficiency in heart failure is well established and pathophysiologic overlap with pulmonary hypertension exists.
UNASSIGNED: Iron deficiency is common co-morbidity in heart failure and pulmonary hypertension. The high prevalence is intertwined into the pathophysiology of these conditions (e.g., neurohormonal activation, inflammation). The presence of iron deficiency has a negative impact on cardiomyocytes and cardiac function, skeletal muscle function, and pulmonary vascular function. In heart failure data from over 2000 randomized patients with iron deficiency using a uniform diagnosis, have illustrated beneficial effects on functional status, quality of life, reverse cardiac remodeling, and heart failure admissions. While iron deficiency is recognized to be prevalent in pulmonary hypertension and associated with worse functional status, the absence of a uniform definition and the absence of large prospective randomized controlled trials with iron therapies limits the conclusions on the causal role of iron deficiency such as observed in heart failure.
UNASSIGNED: To role of iron deficiency in heart failure is well established and pathophysiologic overlap with pulmonary hypertension exists.
UNASSIGNED: Iron deficiency is common co-morbidity in heart failure and pulmonary hypertension. The high prevalence is intertwined into the pathophysiology of these conditions (e.g., neurohormonal activation, inflammation). The presence of iron deficiency has a negative impact on cardiomyocytes and cardiac function, skeletal muscle function, and pulmonary vascular function. In heart failure data from over 2000 randomized patients with iron deficiency using a uniform diagnosis, have illustrated beneficial effects on functional status, quality of life, reverse cardiac remodeling, and heart failure admissions. While iron deficiency is recognized to be prevalent in pulmonary hypertension and associated with worse functional status, the absence of a uniform definition and the absence of large prospective randomized controlled trials with iron therapies limits the conclusions on the causal role of iron deficiency such as observed in heart failure.
摘要：
■描述缺铁在心力衰竭和肺动脉高压中的作用。
■铁缺乏在心力衰竭中的作用已被明确，并且与肺动脉高压存在病理生理重叠。
■缺铁是心力衰竭和肺动脉高压的常见合并症。高患病率与这些病症的病理生理学交织在一起(例如，神经激素激活，炎症)。缺铁的存在对心肌细胞和心脏功能有负面影响，骨骼肌功能，和肺血管功能。在来自2000多个随机缺铁患者的心力衰竭数据中，使用统一诊断，已经说明了对功能状态的有益影响，生活质量,逆转心脏重塑，和心力衰竭入院。虽然人们认为缺铁在肺动脉高压中很普遍，并且与更差的功能状态有关，缺乏统一的定义,以及缺乏使用铁疗法的大型前瞻性随机对照试验,限制了对铁缺乏的因果作用的结论,如在心力衰竭中观察到的结论.
■铁缺乏在心力衰竭中的作用已被明确，并且与肺动脉高压存在病理生理重叠。
■缺铁是心力衰竭和肺动脉高压的常见合并症。高患病率与这些病症的病理生理学交织在一起(例如，神经激素激活，炎症)。缺铁的存在对心肌细胞和心脏功能有负面影响，骨骼肌功能，和肺血管功能。在来自2000多个随机缺铁患者的心力衰竭数据中，使用统一诊断，已经说明了对功能状态的有益影响，生活质量,逆转心脏重塑，和心力衰竭入院。虽然人们认为缺铁在肺动脉高压中很普遍，并且与更差的功能状态有关，缺乏统一的定义,以及缺乏使用铁疗法的大型前瞻性随机对照试验,限制了对铁缺乏的因果作用的结论,如在心力衰竭中观察到的结论.
