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Abstract：
Background: Innovative treatment strategies for early-stage breast cancer (BC) are urgently needed. Tumors originating from mammary ductal cells present an opportunity for targeted intervention. Methods: We explored intraductal therapy via natural nipple openings as a promising non-invasive approach for early BC. Using functional Near-infrared II (NIR-II) nanomaterials, specifically NIR-IIb quantum dots conjugated with Epep polypeptide for ductal cell targeting, we conducted in situ imaging and photothermal ablation of mammary ducts. Intraductal administration was followed by stimulation with an 808 nm laser. Results: This method achieved precise ductal destruction and heightened immunological responses in the microenvironment. The technique was validated in mouse models of triple-negative BC and a rat model of ductal carcinoma in situ, demonstrating promising therapeutic potential for localized BC treatment and prevention. Conclusion: Our study demonstrated the effectiveness of NIR-II nanoprobes in guiding non-invasive photothermal ablation of mammary ducts, offering a compelling avenue for early-stage BC therapy.
摘要：
背景：早期乳腺癌（BC）迫切需要创新的治疗策略。源自乳腺导管细胞的肿瘤提供了靶向干预的机会。方法：我们探索了通过自然乳头开口进行导管内治疗作为早期BC的一种有希望的非侵入性方法。使用功能性近红外II（NIR-II）纳米材料，特别是NIR-IIb量子点与Epep多肽缀合，用于导管细胞靶向，我们对乳腺导管进行了原位成像和光热消融。导管内给药之后用808nm激光进行刺激。结果：该方法在微环境中实现了精确的导管破坏和增强的免疫反应。该技术在三阴性BC小鼠模型和导管原位癌大鼠模型中得到了验证，证明了局部BC治疗和预防的有希望的治疗潜力。结论：我们的研究证明了NIR-II纳米探针在引导乳腺导管的非侵入性光热消融中的有效性，为早期BC治疗提供了一条引人注目的途径。
