PDF(Pubmed)
Abstract：
UNASSIGNED: The demographics of donor and recipient candidates for kidney transplantation (KT) have substantially changed. Recipients tend to be older and polymorbid and KT to suboptimal recipients is associated with delayed graft function (DGF), prolonged hospitalization, inferior long-term allograft function, and poorer patient survival. In parallel, donors are also older, suffer from several comorbidities, and donations coming from circulatory death (DCD) predominate, which in turn leads to early and late complications. However, it is unclear how donor and recipient risk factors interact.
UNASSIGNED: In this retrospective cohort study, we assess the impact of a KT from suboptimal donors to suboptimal recipients. We focused on: 1) DGF; 2) hospital stay and number of dialysis days after KT and 3) allograft function at 12 months.
UNASSIGNED: Among the 369 KT included, the overall DGF rate was 25% (n = 92) and median time from reperfusion to DGF resolution was 7.8 days (IQR: 3.0-13.8 days). Overall, patients received four dialysis sessions (IQR: 2-8). The combination of pre-KT anuria (<200 ml/24 h, 32%) and DCD procurement (14%) was significantly associated with DGF, length of hospital stay, and severe perioperative complications, predominantly in recipients 50 years and older.
UNASSIGNED: In this retrospective cohort study, we assess the impact of a KT from suboptimal donors to suboptimal recipients. We focused on: 1) DGF; 2) hospital stay and number of dialysis days after KT and 3) allograft function at 12 months.
UNASSIGNED: Among the 369 KT included, the overall DGF rate was 25% (n = 92) and median time from reperfusion to DGF resolution was 7.8 days (IQR: 3.0-13.8 days). Overall, patients received four dialysis sessions (IQR: 2-8). The combination of pre-KT anuria (<200 ml/24 h, 32%) and DCD procurement (14%) was significantly associated with DGF, length of hospital stay, and severe perioperative complications, predominantly in recipients 50 years and older.
摘要：
■肾移植（KT）的供体和受体候选人的人口统计学特征发生了实质性变化。受者往往年龄较大且多态，对次优受者的KT与移植物功能延迟（DGF）有关，住院时间延长,同种异体移植长期功能较差，患者生存率较差。并行,捐赠者也更老了，患有多种合并症，来自循环系统死亡（DCD）的捐赠占主导地位，这反过来又导致早期和晚期并发症。然而,目前尚不清楚供体和受体风险因素如何相互作用.
■在这项回顾性队列研究中，我们评估了来自次优供体的KT对次优受体的影响.我们关注：1）DGF；2）KT后的住院时间和透析天数，3）12个月的同种异体移植功能。
■在包括的369KT中，总DGF率为25%(n=92),从再灌注到DGF消退的中位时间为7.8天(IQR:3.0~13.8天).总的来说,患者接受了4次透析(IQR:2-8).前KT无尿症的组合(<200毫升/24小时，32%)和DCD采购(14%)与DGF显著相关，住院时间,严重的围手术期并发症，主要是50岁及以上的接受者。
■在这项回顾性队列研究中，我们评估了来自次优供体的KT对次优受体的影响.我们关注：1）DGF；2）KT后的住院时间和透析天数，3）12个月的同种异体移植功能。
■在包括的369KT中，总DGF率为25%(n=92),从再灌注到DGF消退的中位时间为7.8天(IQR:3.0~13.8天).总的来说,患者接受了4次透析(IQR:2-8).前KT无尿症的组合(<200毫升/24小时，32%)和DCD采购(14%)与DGF显著相关，住院时间,严重的围手术期并发症，主要是50岁及以上的接受者。
