PDF(Pubmed)
Abstract：
Both age and biological sex affect transplantation outcomes. We have recently shown in a large volume clinical analysis utilizing the SRTR data that graft survival is inferior in young female kidney transplant recipients. In this multi-factorial analysis, older female recipients presented with a trend towards improved transplant outcomes compared to both young female recipients and male recipients of any age. Those data supported by reports of those of others suggest that sex and age impact alloimmune responses both, individually and synergistically. Biological sex and hormone levels change throughout a lifetime with recognized effects on longevity in addition to an impact on the development and course of several disease preconditions. Detailed mechanisms of those sex and age-specific aspects have thus far been studied outside of transplantation. Effects on alloimmunity are largely unknown. Moreover, the combinatorial impact that both, biological sex and age have on transplant outcomes is not understood. Here, we summarize available data that analyze how age in combination with biological sex may shape alloimmune responses and affect transplant outcomes.
摘要：
年龄和生物性别都会影响移植结果。我们最近在利用SRTR数据的大量临床分析中表明，年轻女性肾移植受者的移植物存活率较低。在这种多因素分析中，与年轻女性接受者和任何年龄的男性接受者相比,老年女性接受者的移植结局有改善的趋势.其他报告支持的数据表明，性别和年龄都会影响同种免疫反应，单独和协同。生物性别和激素水平在一生中都会发生变化，除了对几种疾病的发展和进程有影响外，还对寿命产生公认的影响。迄今为止，在移植之外已经研究了这些性别和年龄特异性方面的详细机制。对同种免疫的影响在很大程度上是未知的。此外，两者的组合影响，生物学性别和年龄对移植结果的影响尚不清楚。这里,我们总结了现有数据,这些数据分析了年龄与生物性别相结合如何影响同种免疫反应并影响移植结局.
