PDF(Pubmed)
Abstract：
Kidney transplantation is a well-established alternative to renal replacement therapy. Although the number of patients with end-stage renal disease (ESRD) is increasing, the availability of kidney for transplantation is still insufficient to meet the needs. As age increases, the prevalence of ESRD increases; thus, the population of aged donors and recipients occupies large proportion. Accumulated senescent cells secrete pro-inflammatory factors and induce senescence. Additionally, it is gradually becoming clear that biological sex differences can influence aging and cause differences in senescence. Here, we review whether age-related sex differences affect organ transplant outcomes and what should be done in the future.
摘要：
肾移植是肾脏替代疗法的公认替代方法。尽管终末期肾病（ESRD）的患者数量正在增加，可供移植的肾脏仍然不足以满足需要。随着年龄的增长,ESRD的患病率增加；因此，老年捐献者和接受者的人口比例很大。积累的衰老细胞分泌促炎因子并诱导衰老。此外,逐渐清楚的是，生物性别差异可以影响衰老并导致衰老的差异。这里,我们回顾了年龄相关的性别差异是否会影响器官移植结局,以及今后应该采取的措施.
