PDF(Pubmed)
Abstract：
Exosomal microRNAs (miRNAs) have great potential in the fight against hepatocellular carcinoma (HCC), the fourth most common cause of cancer-related death worldwide. In this study, we explored the various applications of these small molecules while analyzing their complex roles in tumor development, metastasis, and changes in the tumor microenvironment. We also discussed the complex interactions that exist between exosomal miRNAs and other non-coding RNAs such as circular RNAs, and show how these interactions coordinate important biochemical pathways that propel the development of HCC. The possibility of targeting exosomal miRNAs for therapeutic intervention is paramount, even beyond their mechanistic significance. We also highlighted their growing potential as cutting-edge biomarkers that could lead to tailored treatment plans by enabling early identification, precise prognosis, and real-time treatment response monitoring. This thorough analysis revealed an intricate network of exosomal miRNAs lead to HCC progression. Finally, strategies for purification and isolation of exosomes and advanced biosensing techniques for detection of exosomal miRNAs are also discussed. Overall, this comprehensive review sheds light on the complex web of exosomal miRNAs in HCC, offering valuable insights for future advancements in diagnosis, prognosis, and ultimately, improved outcomes for patients battling this deadly disease.
摘要：
外泌体microRNAs（miRNAs）在对抗肝细胞癌（HCC）方面具有巨大的潜力，全球癌症相关死亡的第四大常见原因。在这项研究中,我们探索了这些小分子的各种应用，同时分析了它们在肿瘤发展中的复杂作用，转移,和肿瘤微环境的变化。我们还讨论了外泌体miRNA和其他非编码RNA如环状RNA之间存在的复杂相互作用。并显示这些相互作用如何协调推动HCC发展的重要生化途径。靶向外泌体miRNA用于治疗性干预的可能性是至关重要的，甚至超出了它们的机械意义。我们还强调了它们作为尖端生物标志物的增长潜力，可以通过早期识别来制定量身定制的治疗计划，精确的预后，和实时治疗反应监测。这种彻底的分析揭示了外泌体miRNA的复杂网络导致HCC进展。最后,还讨论了外泌体纯化和分离的策略以及用于检测外泌体miRNAs的先进生物传感技术。总的来说,这篇全面的综述揭示了肝癌外泌体miRNA的复杂网络，为诊断的未来进步提供有价值的见解，预后,最终,改善与这种致命疾病作斗争的患者的预后。
