PDF(Pubmed)
Abstract：
Stage IVA cervical cancer is a tumor that invades the mucosa of the bladder or rectum without distant metastasis and is difficult to treat, and concurrent chemoradiotherapy is recommended. Although radical surgery following neoadjuvant chemotherapy is a treatment option for stage IVA cervical cancer, the evidence is limited. A 51-year-old woman with bulky cervical cancer and rectal invasion was referred to our hospital. Paclitaxel and cisplatin were administered as neoadjuvant chemotherapies. After two cycles of chemotherapy, the tumor size decreased markedly. Total pelvic exenteration was performed, and a complete resection was achieved. Four cycles of paclitaxel and cisplatin were administered postoperatively. Thirty-three months after the completion of adjuvant chemotherapy, the patient was alive and free of disease. Radical surgery after neoadjuvant chemotherapy may be a treatment option for stage IVA cervical cancer with bulky tumors.
摘要：
IVA期宫颈癌是一种侵入膀胱或直肠粘膜而无远处转移且难以治疗的肿瘤，并建议同步放化疗。尽管新辅助化疗后的根治性手术是IVA期宫颈癌的治疗选择，证据是有限的。一名51岁的女性患有巨大的宫颈癌和直肠侵犯，被转诊到我们医院。紫杉醇和顺铂作为新辅助化疗。经过两个周期的化疗,肿瘤大小明显减小。进行全盆腔切除术,并实现了完全切除。术后给予紫杉醇和顺铂4个周期。辅助化疗完成后三十三个月，病人还活着，没有疾病。新辅助化疗后的根治性手术可能是IVA期宫颈癌大肿瘤的治疗选择。
