PDF(Pubmed)
Abstract：
Hematopoiesis represents a meticulously regulated and dynamic biological process. Genetic aberrations affecting blood cells, induced by various factors, frequently give rise to hematological tumors. These instances are often accompanied by a multitude of abnormal post-transcriptional regulatory events, including RNA alternative splicing, RNA localization, RNA degradation, and storage. Notably, post-transcriptional regulation plays a pivotal role in preserving hematopoietic homeostasis. The DEAD-Box RNA helicase genes emerge as crucial post-transcriptional regulatory factors, intricately involved in sustaining normal hematopoiesis through diverse mechanisms such as RNA alternative splicing, RNA modification, and ribosome assembly. This review consolidates the existing knowledge on the role of DEAD-box RNA helicases in regulating normal hematopoiesis and underscores the pathogenicity of mutant DEAD-Box RNA helicases in malignant hematopoiesis. Emphasis is placed on elucidating both the positive and negative contributions of DEAD-box RNA helicases within the hematopoietic system.
摘要：
造血代表了精心调节和动态的生物过程。影响血细胞的遗传畸变，由各种因素引起，经常引起血液肿瘤。这些情况通常伴随着大量异常的转录后调控事件，包括RNA选择性剪接，RNA定位,RNA降解，和存储。值得注意的是,转录后调控在维持造血稳态中起着关键作用。DEAD-BoxRNA解旋酶基因作为关键的转录后调控因子，复杂的参与维持正常的造血通过不同的机制，如RNA可变剪接，RNA修饰，和核糖体组装。这篇综述巩固了关于DEAD-boxRNA解旋酶在调节正常造血中的作用的现有知识，并强调了突变的DEAD-BoxRNA解旋酶在恶性造血中的致病性。重点放在阐明造血系统中DEAD-boxRNA解旋酶的正负贡献。
