UNASSIGNED: The aim of this study was to evaluate the adequacy of IS regimen minimization strategy in kidney transplant recipients hospitalized in an ICU for severe COVID-19, in relation to the issued recommendations.
UNASSIGNED: The immunosuppressive therapy was minimized in all patients, with respectively 63% and 59% of the patients meeting the local and european recommendations upon admission. During ICU stay, IS was further tapered leading to 85% (local) and 78% (european) adequacy, relative to the guidelines. The most frequent deviation was the lack of complete withdrawal of mycophenolic acid (22%). Nevertheless, the adequacy/inadequacy status was not associated to the ICU- or one-year-mortality.
UNASSIGNED: In this single-center cohort, the only variable associated with a reduction in mortality was vaccination, emphasizing that the key issue is immunization prior to infection, not restoration of immunity during ICU stay.
■这项研究的目的是根据已发布的建议,评估在重症COVID-19ICU住院的肾移植受者中IS方案最小化策略的充分性。
■所有患者的免疫抑制治疗都被最小化,分别有63%和59%的患者在入院时符合当地和欧洲的建议。ICU入住期间,IS进一步缩减,导致85%(本地)和78%(欧洲)的充足性,相对于准则。最常见的偏差是缺乏霉酚酸的完全戒断(22%)。然而,充足/不充足状态与ICU或1年死亡率无关.
■在这个单中心队列中,与死亡率降低相关的唯一变量是疫苗接种,强调关键问题是感染前的免疫接种,在ICU入住期间不能恢复免疫力。