PDF(Pubmed)
Abstract：
Multiple primary malignancies (MPMs) occur when an individual develops two or more distinct primary cancers. These are categorized as synchronous or metachronous based on the timing of their diagnosis. Patients previously diagnosed with cancer face increased risks due to exposure to carcinogenic factors and treatments such as chemotherapy and radiotherapy. Individuals with a history of breast cancer are known to have elevated risks for secondary malignancies compared to the general population. However, cases of squamous cell carcinoma (SCC) of the eyelid in this group are exceedingly rare. Here, we present a case report describing a young female patient who sequentially developed metachronous breast cancer, and a human papillomavirus (HPV)-associated SCC of the eyelid. To the best of our knowledge, this case report represents the first documented instance of this specific combination of primary neoplasms in medical literature.
摘要：
当个体发展两种或更多种不同的原发性癌症时,发生多原发性恶性肿瘤(MPM)。根据诊断的时机，将这些分类为同步或异时。先前被诊断患有癌症的患者由于暴露于致癌因素和诸如化疗和放疗的治疗而面临增加的风险。已知具有乳腺癌病史的个体与普通人群相比具有升高的继发性恶性肿瘤风险。然而,该组中眼睑鳞状细胞癌（SCC）的病例极为罕见。这里,我们提供了一个病例报告，描述了一名年轻的女性患者，她依次发展为异时性乳腺癌，和人乳头瘤病毒（HPV）相关的眼睑SCC。据我们所知,该病例报告是医学文献中首次记录的这种原发性肿瘤特定组合的实例.
