PDF(Pubmed)
Abstract：
UNASSIGNED: Healthcare-associated infections (HAI) and antimicrobial use (AMU) are drivers for antimicrobial resistance, and robust data are required to inform interventions and track changes. We aimed to estimate the prevalence of HAI and AMU at Port Moresby General Hospital (PMGH), the largest hospital in Papua New Guinea.
UNASSIGNED: We did a point prevalence survey (PPS) on HAI and AMU at PMGH in May 2023 using the European Centre for Disease Prevention and Control (ECDC) PPS protocol. We included all critical care patients and randomly sampled half of the patients in other acute-care wards. We calculated weighted HAI and AMU prevalence estimates to account for this sampling strategy. Weighted HAI estimates were also calculated for an expanded definition that included physician diagnosis.
UNASSIGNED: Of 361 patients surveyed in 18 wards, the ECDC protocol identified 28 HAIs in 26 patients, resulting in a weighted HAI prevalence of 6.7% (95% CI: 4.6, 9.8). Surgical site infections (9/28, 32%) were the most common HAI. When adding physician diagnosis to the ECDC definitions, more skin and soft tissue, respiratory, and bloodstream HAIs were detected, and the weighted HAI prevalence was 12.4% (95% CI: 9.4, 16.3). The prevalence of AMU was 66.5% (95%CI: 61.3, 71.2), and 73.2% (263/359) of antibiotics were from the World Health Organization Access group.
UNASSIGNED: This is the first reported hospital PPS of HAI and AMU in Papua New Guinea. These results can be used to prioritise interventions, and as a baseline against which future point prevalence surveys can be compared.
UNASSIGNED: Australian Government Department of Foreign Affairs and Trade and Therapeutic Guidelines Limited Australia.
UNASSIGNED: We did a point prevalence survey (PPS) on HAI and AMU at PMGH in May 2023 using the European Centre for Disease Prevention and Control (ECDC) PPS protocol. We included all critical care patients and randomly sampled half of the patients in other acute-care wards. We calculated weighted HAI and AMU prevalence estimates to account for this sampling strategy. Weighted HAI estimates were also calculated for an expanded definition that included physician diagnosis.
UNASSIGNED: Of 361 patients surveyed in 18 wards, the ECDC protocol identified 28 HAIs in 26 patients, resulting in a weighted HAI prevalence of 6.7% (95% CI: 4.6, 9.8). Surgical site infections (9/28, 32%) were the most common HAI. When adding physician diagnosis to the ECDC definitions, more skin and soft tissue, respiratory, and bloodstream HAIs were detected, and the weighted HAI prevalence was 12.4% (95% CI: 9.4, 16.3). The prevalence of AMU was 66.5% (95%CI: 61.3, 71.2), and 73.2% (263/359) of antibiotics were from the World Health Organization Access group.
UNASSIGNED: This is the first reported hospital PPS of HAI and AMU in Papua New Guinea. These results can be used to prioritise interventions, and as a baseline against which future point prevalence surveys can be compared.
UNASSIGNED: Australian Government Department of Foreign Affairs and Trade and Therapeutic Guidelines Limited Australia.
摘要：
■医疗保健相关感染（HAI）和抗菌药物使用（AMU）是抗菌素耐药性的驱动因素，并且需要强大的数据来告知干预措施和跟踪变化。我们旨在估计莫尔兹比港综合医院（PMGH）的HAI和AMU的患病率，巴布亚新几内亚最大的医院。
■我们于2023年5月在PMGH使用欧洲疾病预防和控制中心（ECDC）PPS协议对HAI和AMU进行了点患病率调查（PPS）。我们纳入了所有重症监护患者，并随机抽取了其他急诊病房中一半的患者。我们计算了加权HAI和AMU患病率估计值，以解释这一抽样策略。还计算了包括医师诊断在内的扩展定义的加权HAI估计值。
■在18个病房接受调查的361名患者中，ECDC方案确定了26例患者中的28例HAIs，导致加权HAI患病率为6.7%（95%CI：4.6，9.8）。手术部位感染（9/28，32%）是最常见的HAI。在ECDC定义中添加医师诊断时，更多的皮肤和软组织，呼吸,并检测到血液HAIs，加权HAI患病率为12.4%(95%CI:9.4,16.3)。AMU的患病率为66.5%(95CI:61.3,71.2),73.2%(263/359)的抗生素来自世界卫生组织接入组。
■这是巴布亚新几内亚首次报道的HAI和AMU医院PPS。这些结果可用于优先考虑干预措施，并作为未来点患病率调查可以比较的基线。
■澳大利亚政府外交与贸易部和治疗指南有限公司澳大利亚。
■我们于2023年5月在PMGH使用欧洲疾病预防和控制中心（ECDC）PPS协议对HAI和AMU进行了点患病率调查（PPS）。我们纳入了所有重症监护患者，并随机抽取了其他急诊病房中一半的患者。我们计算了加权HAI和AMU患病率估计值，以解释这一抽样策略。还计算了包括医师诊断在内的扩展定义的加权HAI估计值。
■在18个病房接受调查的361名患者中，ECDC方案确定了26例患者中的28例HAIs，导致加权HAI患病率为6.7%（95%CI：4.6，9.8）。手术部位感染（9/28，32%）是最常见的HAI。在ECDC定义中添加医师诊断时，更多的皮肤和软组织，呼吸,并检测到血液HAIs，加权HAI患病率为12.4%(95%CI:9.4,16.3)。AMU的患病率为66.5%(95CI:61.3,71.2),73.2%(263/359)的抗生素来自世界卫生组织接入组。
■这是巴布亚新几内亚首次报道的HAI和AMU医院PPS。这些结果可用于优先考虑干预措施，并作为未来点患病率调查可以比较的基线。
■澳大利亚政府外交与贸易部和治疗指南有限公司澳大利亚。
