PDF(Pubmed)
Abstract：
UNASSIGNED: Sarcopenia is associated with the prognosis of patients with liver cirrhosis and hepatocellular carcinoma (HCC). Given their diverse physiological activities, we hypothesized that plasma fatty acids might influence the progression of sarcopenia. This study aimed to clarify the association between fatty acids and sarcopenia in cirrhotic patients with HCC.
UNASSIGNED: In this single-center retrospective study, we registered 516 cases and analyzed 414 cases of liver cirrhosis and HCC. The skeletal muscle mass index was measured using a transverse computed tomography scan image at the third lumbar vertebra. The cutoff value for sarcopenia followed the criteria set by the Japan Society of Hepatology. Fatty acid concentrations were measured by gas chromatography.
UNASSIGNED: Fatty acid levels, particularly omega-3 (n-3) polyunsaturated fatty acid (PUFA), were lower in patients with poor liver function (Child-Pugh grade B/C) and were negatively correlated with the albumin-bilirubin score (p<0.0001). The prognosis of HCC patients with low PUFA levels was significantly worse. Among the different fatty acid fractions, only n-3 PUFAs significantly correlated with skeletal muscle mass index (p=0.0026). In the multivariate analysis, the n-3 PUFA level was an independent variable associated with sarcopenia (p=0.0006).
UNASSIGNED: A low level of n-3 PUFAs was associated with sarcopenia in patients with liver cirrhosis and HCC.
UNASSIGNED: In this single-center retrospective study, we registered 516 cases and analyzed 414 cases of liver cirrhosis and HCC. The skeletal muscle mass index was measured using a transverse computed tomography scan image at the third lumbar vertebra. The cutoff value for sarcopenia followed the criteria set by the Japan Society of Hepatology. Fatty acid concentrations were measured by gas chromatography.
UNASSIGNED: Fatty acid levels, particularly omega-3 (n-3) polyunsaturated fatty acid (PUFA), were lower in patients with poor liver function (Child-Pugh grade B/C) and were negatively correlated with the albumin-bilirubin score (p<0.0001). The prognosis of HCC patients with low PUFA levels was significantly worse. Among the different fatty acid fractions, only n-3 PUFAs significantly correlated with skeletal muscle mass index (p=0.0026). In the multivariate analysis, the n-3 PUFA level was an independent variable associated with sarcopenia (p=0.0006).
UNASSIGNED: A low level of n-3 PUFAs was associated with sarcopenia in patients with liver cirrhosis and HCC.
摘要：
■肌肉减少症与肝硬化和肝细胞癌（HCC）患者的预后相关。鉴于他们不同的生理活动，我们假设血浆脂肪酸可能影响肌肉减少症的进展.本研究旨在阐明肝癌肝硬化患者中脂肪酸和肌肉减少症之间的关系。
■在这项单中心回顾性研究中，我们登记了516例，分析了414例肝硬化和HCC。使用第三腰椎的横向计算机断层扫描扫描图像测量骨骼肌质量指数。肌少症的截止值遵循日本肝病学会设定的标准。通过气相色谱法测量脂肪酸浓度。
■脂肪酸水平，特别是omega-3（n-3）多不饱和脂肪酸（PUFA），在肝功能不良（Child-Pugh分级B/C）的患者中，与白蛋白-胆红素评分呈负相关（p<0.0001）。PUFA水平较低的HCC患者预后明显较差。在不同的脂肪酸馏分中，只有n-3PUFA与骨骼肌质量指数显着相关（p=0.0026）。在多变量分析中，n-3PUFA水平是与肌少症相关的独立变量(p=0.0006).
■在肝硬化和HCC患者中，低水平的n-3PUFA与肌肉减少症相关。
■在这项单中心回顾性研究中，我们登记了516例，分析了414例肝硬化和HCC。使用第三腰椎的横向计算机断层扫描扫描图像测量骨骼肌质量指数。肌少症的截止值遵循日本肝病学会设定的标准。通过气相色谱法测量脂肪酸浓度。
■脂肪酸水平，特别是omega-3（n-3）多不饱和脂肪酸（PUFA），在肝功能不良（Child-Pugh分级B/C）的患者中，与白蛋白-胆红素评分呈负相关（p<0.0001）。PUFA水平较低的HCC患者预后明显较差。在不同的脂肪酸馏分中，只有n-3PUFA与骨骼肌质量指数显着相关（p=0.0026）。在多变量分析中，n-3PUFA水平是与肌少症相关的独立变量(p=0.0006).
■在肝硬化和HCC患者中，低水平的n-3PUFA与肌肉减少症相关。
