PDF(Pubmed)
Abstract：
The incidence of autoimmune liver diseases (ALDs) and research on their pathogenesis are increasing annually. However, except for autoimmune hepatitis, which responds well to immunosuppression, primary biliary cholangitis and primary sclerosing cholangitis are insensitive to immunosuppressive therapy. Besides the known effects of the environment, genetics, and immunity on ALDs, the heterogeneity of target cells provides new insights into their pathogenesis. This review started by exploring the heterogeneity in the development, structures, and functions of hepatocytes and epithelial cells of the small and large bile ducts. For example, cytokeratin (CK) 8 and CK18 are primarily expressed in hepatocytes, while CK7 and CK19 are primarily expressed in intrahepatic cholangiocytes. Additionally, emerging technologies of single-cell RNA sequencing and spatial transcriptomic are being applied to study ALDs. This review offered a new perspective on understanding the pathogenic mechanisms and potential treatment strategies for ALDs.
摘要：
自身免疫性肝病（ALDs）的发病率和发病机制的研究逐年增加。然而,除了自身免疫性肝炎,对免疫抑制反应良好，原发性胆汁性胆管炎和原发性硬化性胆管炎对免疫抑制治疗不敏感。除了已知的环境影响，遗传学,和ALD的豁免权，靶细胞的异质性为其发病机制提供了新的见解。这篇综述首先探讨了发展中的异质性，结构,以及小胆管和大胆管的肝细胞和上皮细胞的功能。例如,细胞角蛋白（CK）8和CK18主要在肝细胞中表达，而CK7和CK19主要在肝内胆管细胞中表达。此外,单细胞RNA测序和空间转录组学的新兴技术正被应用于ALD的研究。这篇综述为了解ALDs的致病机制和潜在治疗策略提供了新的视角。
