PDF(Pubmed)
Abstract：
UNASSIGNED: Observational investigations have examined the impact of glucosamine use on the risk of cancer and non-neoplastic diseases. However, the findings from these studies face limitations arising from confounding variables, reverse causation, and conflicting reports. Consequently, the establishment of a causal relationship between habitual glucosamine consumption and the risk of cancer and non-neoplastic diseases necessitates further investigation.
UNASSIGNED: For Mendelian randomization (MR) investigation, we opted to employ single-nucleotide polymorphisms (SNPs) as instruments that exhibit robust associations with habitual glucosamine consumption. We obtained the corresponding effect estimates of these SNPs on the risk of cancer and non-neoplastic diseases by extracting summary data for genetic instruments linked to 49 varied cancer types amounting to 378,284 cases and 533,969 controls, as well as 20 non-neoplastic diseases encompassing 292,270 cases and 842,829 controls. Apart from the primary analysis utilizing inverse-variance weighted MR, we conducted two supplementary approaches to account for potential pleiotropy (MR-Egger and weighted median) and assessed their respective MR estimates. Furthermore, the results of the leave-one-out analysis revealed that there were no outlying instruments.
UNASSIGNED: Our results suggest divergence from accepted biological understanding, suggesting that genetically predicted glucosamine utilization may be linked to an increased vulnerability to specific illnesses, as evidenced by increased odds ratios and confidence intervals (95% CI) for diseases, such as malignant neoplasm of the eye and adnexa (2.47 [1.34-4.55]), benign neoplasm of the liver/bile ducts (2.12 [1.32-3.43]), benign neoplasm of the larynx (2.01 [1.36-2.96]), melanoma (1.74 [1.17-2.59]), follicular lymphoma (1.50 [1.06-2.11]), autoimmune thyroiditis (2.47 [1.49-4.08]), and autoimmune hyperthyroidism (1.93 [1.17-3.18]). In contrast to prior observational research, our genetic investigations demonstrate a positive correlation between habitual glucosamine consumption and an elevated risk of sigmoid colon cancer, lung adenocarcinoma, and benign neoplasm of the thyroid gland.
UNASSIGNED: Casting doubt on the purported purely beneficial association between glucosamine ingestion and prevention of neoplastic and non-neoplastic diseases, habitual glucosamine ingestion exhibits dichotomous effects on disease outcomes. Endorsing the habitual consumption of glucosamine as a preventative measure against neoplastic and non-neoplastic diseases cannot be supported.
UNASSIGNED: For Mendelian randomization (MR) investigation, we opted to employ single-nucleotide polymorphisms (SNPs) as instruments that exhibit robust associations with habitual glucosamine consumption. We obtained the corresponding effect estimates of these SNPs on the risk of cancer and non-neoplastic diseases by extracting summary data for genetic instruments linked to 49 varied cancer types amounting to 378,284 cases and 533,969 controls, as well as 20 non-neoplastic diseases encompassing 292,270 cases and 842,829 controls. Apart from the primary analysis utilizing inverse-variance weighted MR, we conducted two supplementary approaches to account for potential pleiotropy (MR-Egger and weighted median) and assessed their respective MR estimates. Furthermore, the results of the leave-one-out analysis revealed that there were no outlying instruments.
UNASSIGNED: Our results suggest divergence from accepted biological understanding, suggesting that genetically predicted glucosamine utilization may be linked to an increased vulnerability to specific illnesses, as evidenced by increased odds ratios and confidence intervals (95% CI) for diseases, such as malignant neoplasm of the eye and adnexa (2.47 [1.34-4.55]), benign neoplasm of the liver/bile ducts (2.12 [1.32-3.43]), benign neoplasm of the larynx (2.01 [1.36-2.96]), melanoma (1.74 [1.17-2.59]), follicular lymphoma (1.50 [1.06-2.11]), autoimmune thyroiditis (2.47 [1.49-4.08]), and autoimmune hyperthyroidism (1.93 [1.17-3.18]). In contrast to prior observational research, our genetic investigations demonstrate a positive correlation between habitual glucosamine consumption and an elevated risk of sigmoid colon cancer, lung adenocarcinoma, and benign neoplasm of the thyroid gland.
UNASSIGNED: Casting doubt on the purported purely beneficial association between glucosamine ingestion and prevention of neoplastic and non-neoplastic diseases, habitual glucosamine ingestion exhibits dichotomous effects on disease outcomes. Endorsing the habitual consumption of glucosamine as a preventative measure against neoplastic and non-neoplastic diseases cannot be supported.
摘要：
■观察性调查研究了使用氨基葡萄糖对癌症和非肿瘤性疾病风险的影响。然而,这些研究的结果面临着来自混杂变量的局限性，反向因果关系，相互矛盾的报告。因此,建立习惯性的葡糖胺消费与癌症和非肿瘤性疾病风险之间的因果关系需要进一步研究.
■对于孟德尔随机化(MR)调查，我们选择使用单核苷酸多态性(SNPs)作为与习惯性的葡糖胺消耗有显著关联的工具.我们通过提取与49种不同癌症类型相关的遗传工具的汇总数据，获得了这些SNP对癌症和非肿瘤性疾病风险的相应影响估计，总计378,284例病例和53,969例对照。以及20种非肿瘤性疾病，包括292,270例病例和842,829例对照。除了使用逆方差加权MR的主要分析之外，我们采用了两种补充方法来考虑潜在多效性(MR-Egger和加权中位数),并评估了各自的MR估计值.此外，留一分析结果显示，没有外围仪器。
■我们的结果表明与公认的生物学理解存在分歧，表明基因预测的葡糖胺利用可能与特定疾病的脆弱性增加有关，正如疾病的比值比和置信区间(95%CI)增加所证明的那样，如眼睛和附件的恶性肿瘤（2.47[1.34-4.55]），肝脏/胆管良性肿瘤（2.12[1.32-3.43]），喉良性肿瘤（2.01[1.36-2.96]），黑色素瘤（1.74[1.17-2.59]），滤泡性淋巴瘤（1.50[1.06-2.11]），自身免疫性甲状腺炎（2.47[1.49-4.08]），和自身免疫性甲状腺功能亢进（1.93[1.17-3.18]）。与之前的观察研究相比，我们的遗传研究表明，习惯性的葡糖胺消费与乙状结肠癌风险升高之间存在正相关，肺腺癌,甲状腺良性肿瘤。
■对葡萄糖胺摄入与预防肿瘤性和非肿瘤性疾病之间所谓的纯粹有益联系产生怀疑，习惯性摄入氨基葡萄糖对疾病结局具有二分效应。不能支持习惯性地食用葡糖胺作为预防肿瘤和非肿瘤疾病的预防措施。
■对于孟德尔随机化(MR)调查，我们选择使用单核苷酸多态性(SNPs)作为与习惯性的葡糖胺消耗有显著关联的工具.我们通过提取与49种不同癌症类型相关的遗传工具的汇总数据，获得了这些SNP对癌症和非肿瘤性疾病风险的相应影响估计，总计378,284例病例和53,969例对照。以及20种非肿瘤性疾病，包括292,270例病例和842,829例对照。除了使用逆方差加权MR的主要分析之外，我们采用了两种补充方法来考虑潜在多效性(MR-Egger和加权中位数),并评估了各自的MR估计值.此外，留一分析结果显示，没有外围仪器。
■我们的结果表明与公认的生物学理解存在分歧，表明基因预测的葡糖胺利用可能与特定疾病的脆弱性增加有关，正如疾病的比值比和置信区间(95%CI)增加所证明的那样，如眼睛和附件的恶性肿瘤（2.47[1.34-4.55]），肝脏/胆管良性肿瘤（2.12[1.32-3.43]），喉良性肿瘤（2.01[1.36-2.96]），黑色素瘤（1.74[1.17-2.59]），滤泡性淋巴瘤（1.50[1.06-2.11]），自身免疫性甲状腺炎（2.47[1.49-4.08]），和自身免疫性甲状腺功能亢进（1.93[1.17-3.18]）。与之前的观察研究相比，我们的遗传研究表明，习惯性的葡糖胺消费与乙状结肠癌风险升高之间存在正相关，肺腺癌,甲状腺良性肿瘤。
■对葡萄糖胺摄入与预防肿瘤性和非肿瘤性疾病之间所谓的纯粹有益联系产生怀疑，习惯性摄入氨基葡萄糖对疾病结局具有二分效应。不能支持习惯性地食用葡糖胺作为预防肿瘤和非肿瘤疾病的预防措施。
