PDF(Pubmed)
Abstract：
Lactate, a metabolic byproduct, has gained recognition as a highly influential signaling molecule. Lactylation, an emerging form of post-translational modification derived from lactate, plays a crucial role in numerous cellular processes such as inflammation, embryonic development, tumor proliferation, and metabolism. However, the precise molecular mechanisms through which lactylation governs these biological functions in both physiological and pathological contexts remain elusive. Hence, it is imperative to provide a comprehensive overview of lactylation in order to elucidate its significance in biological processes and establish a foundation for forthcoming investigations. This review aims to succinctly outline the process of lactylation modification and the characterization of protein lactylation across diverse organisms. Additionally, A summary of the regulatory mechanisms of lactylation in cellular processes and specific diseases is presented. Finally, this review concludes by delineating existing research gaps in lactylation and proposing primary directions for future investigations.
摘要：
乳酸,代谢副产物，已被公认为具有高度影响力的信号分子。Lactylation,一种源自乳酸的翻译后修饰的新兴形式，在许多细胞过程中起着至关重要的作用，如炎症，胚胎发育,肿瘤增殖，和新陈代谢。然而,确切的分子机制，通过它来控制这些生物学功能，在生理和病理的情况下，仍然难以捉摸。因此，必须提供全面的乳酸化概述，以阐明其在生物过程中的重要性，并为即将进行的研究奠定基础。这篇综述旨在简洁地概述在不同生物中的乳酸化修饰过程和蛋白质乳酸化的表征。此外,总结了细胞过程和特定疾病中乳酸化的调节机制。最后,这篇综述总结了目前在乳酸化方面的研究差距，并提出了未来研究的主要方向。
