PDF(Pubmed)
Abstract：
Background Malnutrition is strongly associated with lower quality of life (QoL) and lower survival rates in patients with end-stage kidney disease. However, the impact of renal transplantation on nutrition factors and QoL is unclear. Therefore, this study aims to assess changes in QoL and investigate the relationships with nutrition factors among kidney transplant recipients (KTRs). Materials and methods A longitudinal study included 86 dialysis patients aged 18-65 years who underwent primary kidney transplantation (KTx) and were followed up for one year. Body weight, biochemical parameters, and QoL data were collected before transplantation (T0) and at six months (T6) and 12 months (T12) post-transplantation. Effect size (ES) was used to measure the impact of KTx on QoL and nutritional status from T0 to T12. The predictors of QoL were calculated with β-coefficients and p<0.05 in linear regression. Results The ES of transplantation on the QoL of KTRs was large, at 1.1 for health change, 0.9 for physical health, and moderate (0.7) for mental health (MH) over one year. Hemoglobin and malnourished were affected by KTx, with ES being 2.4 and 0.6, respectively. Linear regression showed that physical health was predicted by hemoglobin (β=0.12, p<0.01), phosphorus (β=7.82, p<0.05), and dose of mycophenolate mofetil (MMF) (β=-0.01, p<0.05). Mental health was predicted by obesity (β=-7.63, p<0.05), hemoglobin (β=0.11, p<0.05), and phosphorus (β=8.49, p<0.01). Health change was indicated by nutritional risk index (NRI) score (β=0.47, p<0.05), total cholesterol (β=3.39, p<0.01), and kidney function (β=0.15, p<0.05). Conclusions The transition from end-stage kidney disease to transplantation has positive impacts on QoL and nutrition markers. Nutritional status, kidney function, and the dose of mycophenolate mofetil are significant determinants of QoL in KTRs.
摘要：
研究背景：在终末期肾病患者中，营养不良与较低的生活质量（QoL）和较低的生存率密切相关。然而,肾移植对营养因素和生活质量的影响尚不清楚。因此,本研究旨在评估肾移植受者(KTRs)的QoL变化,并探讨其与营养因素的关系.材料和方法一项纵向研究包括86名年龄在18-65岁之间的透析患者，他们接受了原发性肾移植（KTx）并随访了一年。体重,生化参数，收集移植前（T0）和移植后6个月（T6）和12个月（T12）的QoL数据。使用效应大小(ES)来测量从T0到T12的KTx对QoL和营养状况的影响。用β系数计算QoL的预测因子，线性回归p<0.05。结果移植对KTRsQoL的影响较大，在1.1为健康变化，0.9为身体健康，一年以上的心理健康（MH）和中度（0.7）。血红蛋白和营养不良受KTx影响，ES分别为2.4和0.6。线性回归分析显示,血红蛋白(β=0.12,p<0.01)可预测身体健康,磷(β=7.82，p<0.05)，和霉酚酸酯（MMF）的剂量（β=-0.01，p<0.05）。肥胖可预测心理健康（β=-7.63，p<0.05），血红蛋白（β=0.11，p<0.05），磷(β=8.49,p<0.01)。营养风险指数（NRI）评分（β=0.47，p<0.05）显示健康变化，总胆固醇(β=3.39,p<0.01),和肾功能（β=0.15，p<0.05）。结论从终末期肾脏疾病到移植的转变对QoL和营养指标有积极影响。营养状况,肾功能,霉酚酸酯的剂量是KTR中QoL的重要决定因素。
