PDF(Pubmed)
Abstract：
Cisplatin is a cancer therapy drug commonly used. It is well-known for its antineoplastic properties, as well as for its numerous adverse effects, particularly its neurotoxicity. Symptoms associated with a central nervous system injury are unusual but can present a diagnostic challenge. Here, we report a case of a 62-year-old patient who was diagnosed with undifferentiated nasopharyngeal carcinoma. Cisplatin-based chemotherapy was administrated. Five days following the second cycle of treatment, the patient presented neurological disorders. A full biological workup and brain imaging were requested and revealed no abnormalities. The diagnosis of cisplatin encephalopathy was then suspected. Twenty days after cessation of cisplatin therapy, the neurological symptoms began to improve. Based on our case and a review of the literature, cisplatin-induced encephalopathy remains unusual. Its diagnosis is based on a combination of clinical, biological, and radiological criteria and requires the exclusion of other etiologies for neurological disorders in a patient being treated for cancer. Treatment is symptomatic and depends on stopping cisplatin therapy. These neurological adverse effects are often transitory and disappear without major repercussions.
摘要：
顺铂是一种常用的癌症治疗药物。它以其抗肿瘤特性而闻名，以及它的许多不利影响，特别是它的神经毒性。与中枢神经系统损伤相关的症状是不寻常的，但可以提出诊断挑战。这里,我们报道一例62岁的患者,诊断为未分化鼻咽癌.给予顺铂为基础的化疗。第二个治疗周期后五天，患者出现神经系统疾病。要求进行全面的生物检查和脑成像，未发现异常。随后怀疑诊断为顺铂脑病。停止顺铂治疗后20天，神经症状开始好转。根据我们的案例和文献回顾，顺铂引起的脑病仍然不常见。它的诊断基于临床，生物，和放射学标准，并要求排除正在接受癌症治疗的患者的其他神经系统疾病的病因。治疗是对症治疗，取决于停止顺铂治疗。这些神经不良反应通常是短暂的，并且在没有重大影响的情况下消失。
