PDF(Pubmed)
Abstract：
Xanthoma disseminatum (XD) is a rare, non-Langerhans cell histiocytosis. While treatment is notoriously difficult, 2-chlorodeoxyadenosine (cladribine) has recently emerged as a potential effective therapeutic option. Here, we describe the case of a 65-year-old male with XD who experienced significant cutaneous improvement after cladribine treatment. We also provide an updated literature review on cladribine use in patients with XD in light of reported adverse effects (AEs). While the efficacy of cladribine in XD is clear, no consensus exists for treatment duration and AE management. Hence, we strongly encourage interdisciplinary discourse involving dermatology and oncology in these cases.
摘要：
黄色瘤（XD）是一种罕见的，非朗格汉斯细胞组织细胞增生症。虽然治疗是出了名的困难，2-氯脱氧腺苷（克拉屈滨）最近已成为潜在的有效治疗选择。这里,我们描述了一例65岁男性XD患者在接受克拉屈滨治疗后皮肤明显改善.根据报告的不良反应（AE），我们还提供了有关XD患者使用克拉屈滨的最新文献综述。虽然克拉屈滨在XD中的疗效是明确的，对于治疗持续时间和AE管理尚无共识.因此，在这些病例中，我们强烈鼓励涉及皮肤病学和肿瘤学的跨学科讨论。
