PDF(Pubmed)
Abstract：
UNASSIGNED: Studies have shown that increased inflammatory cytokines are associated with suicide risk, but the relationship between suicide risk and inflammatory cytokines is not clear. This study aimed to investigate the relationship between specific inflammatory markers and suicide risk in patients with MDD.
UNASSIGNED: This is a cross-sectional study. Firstly, we measured and compared psychological characteristics and 10 peripheral inflammatory cytokines in 130 MDD patients and 130 healthy controls(HC). Secondly, MDD patients were divided into 4 groups according to the severity of suicide risk for comparison between groups. Finally, multiple linear regression analysis was used to explore the predictors of suicide risk.
UNASSIGNED: We found that the group with higher suicide risk had higher levels of IL-6, CRP, TNF-α, CXCL-2, and IFN-γ, and lower levels of IL-2 and IL-8 (all p<0.01). However, we found no difference in CRP between MIS and LS groups (p=0.337). Regression models were well-fitted. IL-2,IL-8 negatively predicted suicide risk (all p<0.05),IL-6,CRP,TNF-α,CXCL-2, and IFN-γ can positively predict the risk of suicide (all p<0.05).
UNASSIGNED: This study employed a self-assessment scale.
UNASSIGNED: The higher the levels of IL-6, CRP, TNF-α, CXCL-2, and IFN-γ and the lower the levels of IL-2 and IL-8 of MDD patients, the higher the risk of suicide.
UNASSIGNED: This is a cross-sectional study. Firstly, we measured and compared psychological characteristics and 10 peripheral inflammatory cytokines in 130 MDD patients and 130 healthy controls(HC). Secondly, MDD patients were divided into 4 groups according to the severity of suicide risk for comparison between groups. Finally, multiple linear regression analysis was used to explore the predictors of suicide risk.
UNASSIGNED: We found that the group with higher suicide risk had higher levels of IL-6, CRP, TNF-α, CXCL-2, and IFN-γ, and lower levels of IL-2 and IL-8 (all p<0.01). However, we found no difference in CRP between MIS and LS groups (p=0.337). Regression models were well-fitted. IL-2,IL-8 negatively predicted suicide risk (all p<0.05),IL-6,CRP,TNF-α,CXCL-2, and IFN-γ can positively predict the risk of suicide (all p<0.05).
UNASSIGNED: This study employed a self-assessment scale.
UNASSIGNED: The higher the levels of IL-6, CRP, TNF-α, CXCL-2, and IFN-γ and the lower the levels of IL-2 and IL-8 of MDD patients, the higher the risk of suicide.
摘要：
■研究表明，炎症细胞因子的增加与自杀风险有关，但自杀风险与炎症因子之间的关系尚不清楚。本研究旨在探讨MDD患者特异性炎症标志物与自杀风险的关系。
■这是一项横断面研究。首先,我们测量并比较了130例MDD患者和130例健康对照(HC)的心理特征和10种外周炎性细胞因子.其次,MDD患者根据自杀风险的严重程度分为4组进行组间比较。最后,采用多元线性回归分析探讨自杀风险的预测因子.
■我们发现，自杀风险较高的组的IL-6、CRP水平较高，TNF-α,CXCL-2和IFN-γ，和较低水平的IL-2和IL-8(均p<0.01)。然而,我们发现MIS组和LS组之间的CRP没有差异(p=0.337).回归模型拟合良好。IL-2，IL-8负预测自杀风险（所有p<0.05），IL-6,CRP,TNF-α,CXCL-2和IFN-γ可以积极预测自杀风险（均p<0.05）。
■本研究采用了自我评估量表。
■IL-6、CRP水平越高，TNF-α,CXCL-2和IFN-γ水平降低MDD患者的IL-2和IL-8，自杀的风险越高。
■这是一项横断面研究。首先,我们测量并比较了130例MDD患者和130例健康对照(HC)的心理特征和10种外周炎性细胞因子.其次,MDD患者根据自杀风险的严重程度分为4组进行组间比较。最后,采用多元线性回归分析探讨自杀风险的预测因子.
■我们发现，自杀风险较高的组的IL-6、CRP水平较高，TNF-α,CXCL-2和IFN-γ，和较低水平的IL-2和IL-8(均p<0.01)。然而,我们发现MIS组和LS组之间的CRP没有差异(p=0.337).回归模型拟合良好。IL-2，IL-8负预测自杀风险（所有p<0.05），IL-6,CRP,TNF-α,CXCL-2和IFN-γ可以积极预测自杀风险（均p<0.05）。
■本研究采用了自我评估量表。
■IL-6、CRP水平越高，TNF-α,CXCL-2和IFN-γ水平降低MDD患者的IL-2和IL-8，自杀的风险越高。
