PDF(Pubmed)
Abstract：
The cornea is an avascular tissue in the eye that has multiple functions in the eye to maintain clear vision which can significantly impair one\'s vision when subjected to damage. Peroxisome proliferator-activated receptors (PPARs), a family of nuclear receptor proteins comprising three different peroxisome proliferator-activated receptor (PPAR) isoforms, namely, PPAR alpha (α), PPAR gamma (γ), and PPAR delta (δ), have emerged as potential therapeutic targets for treating corneal diseases. In this review, we summarised the current literature on the therapeutic effects of PPAR agents on corneal diseases. We discussed the role of PPARs in the modulation of corneal wound healing, suppression of corneal inflammation, neovascularisation, fibrosis, stimulation of corneal nerve regeneration, and amelioration of dry eye by inhibiting oxidative stress within the cornea. We also discussed the underlying mechanisms of these therapeutic effects. Future clinical trials are warranted to further attest to the clinical therapeutic efficacy.
摘要：
角膜是眼睛中的无血管组织,其在眼睛中具有维持清晰视力的多种功能,当受到损伤时,其可显著损害人的视力。过氧化物酶体增殖物激活受体（PPARs），包含三种不同过氧化物酶体增殖物激活受体（PPAR）亚型的核受体蛋白家族，即,PPARα（α），PPARγ（γ），和PPARδ(δ)，已经成为治疗角膜疾病的潜在治疗靶点。在这次审查中,我们总结了目前有关PPAR药物对角膜疾病的治疗作用的文献。我们讨论了PPARs在调节角膜伤口愈合中的作用，抑制角膜炎症，新生血管化,纤维化，刺激角膜神经再生，并通过抑制角膜内的氧化应激来改善干眼症。我们还讨论了这些治疗作用的潜在机制。未来的临床试验有必要进一步证明临床治疗效果。
