Abstract：
Chlorpyrifos (CPF) is a widely used organophosphate insecticide that has been linked to detrimental health effects that range from neurological impacts to respiratory disease. The objective of this study was to assess respiratory symptoms associated with CPF exposure throughout the application season. Urine samples were collected from Egyptian adolescent applicators (n = 206) and non-applicators (n = 72) to assess 3,5,6-trichloro-2-pyridinol (TCPy), a biomarker for CPF exposure, along with spirometry measures to determine lung ventilatory function. Samples were collected over 7 months in 2016. Logistic regression was used to model the odds of reporting wheeze symptoms based on urinary TCPy concentrations while controlling for age and smoking in the household. Ordinal multinomial logistic regression was used to model the percent reference for forced expiratory volume in one second (rFEV1) based on urinary TCPy concentration (µg/g creatinine). Wheezing increased with increasing pesticide exposure (OR = 1.74 (1.32 - 2.31)). There was no statistically significant relationship between rFEV1 and TCPy concentration. Efforts to reduce pesticide exposure should be implemented to prevent the potential onset or exacerbation of any linked respiratory complications in adolescents.
摘要：
毒死蜱（CPF）是一种广泛使用的有机磷酸盐杀虫剂，与从神经系统影响到呼吸道疾病的有害健康影响有关。这项研究的目的是评估整个应用季节与CPF暴露相关的呼吸道症状。从埃及青少年施药者（n=206）和非施药者（n=72）收集尿液样本，以评估3,5,6-三氯-2-吡啶醇（TCPy），CPF暴露的生物标志物，随着肺活量测定措施，以确定肺通气功能。在2016年收集了超过7个月的样本。使用Logistic回归对基于尿TCPy浓度的报告喘息症状的几率进行建模，同时控制家庭中的年龄和吸烟。使用序数多项逻辑回归对基于尿TCPy浓度（µg/g肌酐）的一秒用力呼气量（rFEV1）的百分比参考进行建模。喘息随着农药暴露的增加而增加（OR=1.74（1.32-2.31））。rFEV1与TCPy浓度之间无统计学意义的关系。应努力减少农药暴露，以防止青少年任何相关呼吸道并发症的潜在发作或恶化。
