关键词: 5a-reductase Alopecia areata Nepenthes kampotiana Lecomte testosterone

来  源:   DOI:10.1080/14786419.2024.2377751

Abstract:
There is increasing interest in hair loss treatment because a growing number of people affected. Nepenthes kampotiana Lecomte is known for its anticancer effects, but its potential for preventing hair loss has not been researched. Therefore, this study focused on the hair loss prevention effects of N. kampotiana Lecomte ethanol extract (Nk-EE). The results showed that Nk-EE had a proliferative effect on human follicle dermal papilla cells and inhibited cell death. In vivo experiments using androgenic areata models showed that Nk-EE had a positive effect on a variety of biomarkers such as hair-to-skin ratio, hair type frequency, and hair thickness. The results of this study suggest that Nk-EE has potential as an effective treatment for androgenic alopecia.
摘要:
由于受影响的人越来越多,人们对脱发治疗的兴趣越来越大。猪笼草因其抗癌作用而闻名,但其预防脱发的潜力尚未被研究。因此,这项研究的重点是N.kampotianaLecomte乙醇提取物(Nk-EE)的脱发预防作用。结果表明,Nk-EE对人卵泡毛乳头细胞具有增殖作用,并抑制细胞死亡。使用雄性激素areata模型的体内实验表明,Nk-EE对多种生物标志物(如头发与皮肤的比例)具有积极作用,发型频率,和头发厚度。这项研究的结果表明,Nk-EE具有作为雄激素性脱发的有效治疗方法的潜力。
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