RESULTS: This study involved 190 patients with HF. The total ECW and ICW of both upper and lower extremities were measured, and a high ECW/ICW ratio was defined as an ECW/ICW ratio higher than the median (≥0.636 for men, ≥0.652 for women). Low muscle strength was defined as reduced handgrip strength according to the criteria established by the Asian Working Group for Sarcopenia. Patients with a high ECW/ICW ratio had a lower handgrip strength (21.1 ± 8.1 kg vs. 27.6 ± 9.3 kg, P ≤ 0.05) and 6 min walk distance (329 ± 116 m vs. 440 ± 114 m) than those with a low ECW/ICW ratio. An increasing ECW and/or decreasing ICW was associated with a higher ECW/ICW ratio and a lower handgrip strength (P < 0.05). In the multivariate logistic regression analysis, a high ECW/ICW ratio and low skeletal muscle mass were independently associated with low muscle strength (P < 0.05).
CONCLUSIONS: A high ECW/ICW ratio in limb muscles, that is, the water imbalance of increasing ECW and/or decreasing ICW, is useful in assessing muscle quality in patients with HF.
结果:本研究涉及190例HF患者。测量上肢和下肢的总ECW和ICW,高ECW/ICW比率被定义为ECW/ICW比率高于中位数(男性≥0.636,女性≥0.652)。根据亚洲肌肉减少症工作组制定的标准,将低肌肉力量定义为握力降低。ECW/ICW比率高的患者的握力较低(21.1±8.1kg与27.6±9.3kg,P≤0.05)和6分钟步行距离(329±116mvs.440±114m)比ECW/ICW比值低的那些。ECW增加和/或ICW减少与更高的ECW/ICW比率和更低的握力相关(P<0.05)。在多变量逻辑回归分析中,高ECW/ICW比值和低骨骼肌质量与低肌力独立相关(P<0.05)。
结论:肢体肌肉的ECW/ICW比率很高,也就是说,增加ECW和/或减少ICW的水不平衡,可用于评估HF患者的肌肉质量。