Abstract：
In this review, we aim to summarize recent information about the association of B vitamins with immune-metabolic aspects of depression and their connection with the gut-brain axis.
B vitamins may alter depressive symptoms by many various mechanisms such as reducing oxidative stress, inflammation, gut permeability, controlling epigenetics, modifying the microbiome, and stimulating it to produce many beneficial substances such as short-chain fatty acids or neurotransmitters: norepinephrine, dopamine, serotonin, gamma-aminobutyric acid, and acetylcholine.
Specifically, vitamins B1 (thiamine), B6 (pyridoxine), B9 (folate), and B12 (cyanocobalamin), B2 (riboflavin) have been observed to affect depression. Given probiotic\'s capability to produce vitamins from the B group, and modify intestinal function, inflammation, or metabolic dysfunction, their supplementation might be a possible treatment method for the immunometabolic form of depression. Thus, the intake of certain probiotic bacterial strains simultaneously with controlling the required daily intake of B vitamins may positively affect the course of depression. Circulating B vitamins metabolite levels, especially B9, B12, and B6 may also be biomarkers of depression. Further investigation is needed to find stronger evidence on this topic.
B vitamins may alter depressive symptoms by many various mechanisms such as reducing oxidative stress, inflammation, gut permeability, controlling epigenetics, modifying the microbiome, and stimulating it to produce many beneficial substances such as short-chain fatty acids or neurotransmitters: norepinephrine, dopamine, serotonin, gamma-aminobutyric acid, and acetylcholine.
Specifically, vitamins B1 (thiamine), B6 (pyridoxine), B9 (folate), and B12 (cyanocobalamin), B2 (riboflavin) have been observed to affect depression. Given probiotic\'s capability to produce vitamins from the B group, and modify intestinal function, inflammation, or metabolic dysfunction, their supplementation might be a possible treatment method for the immunometabolic form of depression. Thus, the intake of certain probiotic bacterial strains simultaneously with controlling the required daily intake of B vitamins may positively affect the course of depression. Circulating B vitamins metabolite levels, especially B9, B12, and B6 may also be biomarkers of depression. Further investigation is needed to find stronger evidence on this topic.
摘要：
目的：在这篇综述中，我们旨在总结有关B族维生素与抑郁症的免疫代谢方面的关联及其与肠-脑轴的关系的最新信息。
■B族维生素可能通过多种机制改变抑郁症状，例如减少氧化应激，炎症,肠道通透性，控制表观遗传学，改变微生物组，并刺激它产生许多有益的物质，如短链脂肪酸或神经递质：去甲肾上腺素，多巴胺,血清素,γ-氨基丁酸,还有乙酰胆碱.
结论：具体来说，维生素B1（硫胺素），B6（吡哆醇），B9(叶酸),和B12（氰钴胺），已经观察到B2(核黄素)影响抑郁症。鉴于益生菌从B组中产生维生素的能力，改变肠道功能，炎症,或代谢功能障碍，它们的补充可能是免疫代谢形式抑郁症的一种可能的治疗方法。因此，摄入某些益生菌菌株同时控制所需的每日B族维生素摄入量可能会对抑郁症的病程产生积极影响。循环B族维生素代谢物水平，尤其是B9,B12和B6也可能是抑郁症的生物标志物.需要进一步调查以找到有关此主题的更有力证据。
■B族维生素可能通过多种机制改变抑郁症状，例如减少氧化应激，炎症,肠道通透性，控制表观遗传学，改变微生物组，并刺激它产生许多有益的物质，如短链脂肪酸或神经递质：去甲肾上腺素，多巴胺,血清素,γ-氨基丁酸,还有乙酰胆碱.
结论：具体来说，维生素B1（硫胺素），B6（吡哆醇），B9(叶酸),和B12（氰钴胺），已经观察到B2(核黄素)影响抑郁症。鉴于益生菌从B组中产生维生素的能力，改变肠道功能，炎症,或代谢功能障碍，它们的补充可能是免疫代谢形式抑郁症的一种可能的治疗方法。因此，摄入某些益生菌菌株同时控制所需的每日B族维生素摄入量可能会对抑郁症的病程产生积极影响。循环B族维生素代谢物水平，尤其是B9,B12和B6也可能是抑郁症的生物标志物.需要进一步调查以找到有关此主题的更有力证据。
