PDF(Pubmed)
Abstract：
The process of viruses entering host cells is complex, involving multiple aspects of the molecular organization of the cell membrane, viral proteins, the interaction of receptor molecules, and cellular signaling. Most viruses depend on endocytosis for uptake, when viruses reach the appropriate location, they are released from the vesicles, undergo uncoating, and release their genomes. Heat shock cognate protein 70(HSC70): also known as HSPA8, a protein involved in mediating clathrin-mediated endocytosis (CME), is involved in various viral entry processes. In this mini-review, our goal is to provide a summary of the function of HSC70 in viral entry. Understanding the interaction networks of HSC70 with viral proteins helps to provide new directions for targeted therapeutic strategies against viral infections.
摘要：
病毒进入宿主细胞的过程是复杂的,涉及细胞膜分子组织的多个方面，病毒蛋白，受体分子的相互作用，和细胞信号。大多数病毒依赖于内吞作用的摄取，当病毒到达适当的位置时，它们从囊泡中释放出来，进行退涂，并释放它们的基因组.热休克同源蛋白70（HSC70）：也称为HSPA8，一种参与介导网格蛋白介导的内吞作用（CME）的蛋白质，参与各种病毒进入过程。在这个小型审查中，我们的目标是总结HSC70在病毒进入中的功能.了解HSC70与病毒蛋白的相互作用网络有助于为针对病毒感染的靶向治疗策略提供新的方向。
