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Abstract：
Pediatric low grade brain tumors and neurodevelopmental disorders share proteins, signaling pathways, and networks. They also share germline mutations and an impaired prenatal differentiation origin. They may differ in the timing of the events and proliferation. We suggest that their pivotal distinct, albeit partially overlapping, outcomes relate to the cell states, which depend on their spatial location, and timing of gene expression during brain development. These attributes are crucial as the brain develops sequentially, and single-cell spatial organization influences cell state, thus function. Our underlying premise is that the root cause in neurodevelopmental disorders and pediatric tumors is impaired prenatal differentiation. Data related to pediatric brain tumors, neurodevelopmental disorders, brain cell (sub)types, locations, and timing of expression in the developing brain are scant. However, emerging single cell technologies, including transcriptomic, spatial biology, spatial high-resolution imaging performed over the brain developmental time, could be transformational in deciphering brain pathologies thereby pharmacology.
摘要：
小儿低度脑肿瘤和神经发育障碍共享蛋白质，信号通路，和网络。它们还共享种系突变和受损的产前分化起源。它们可能在事件和增殖的时间上有所不同。我们建议他们关键的独特之处，尽管部分重叠，结果与细胞状态有关，这取决于它们的空间位置，和大脑发育过程中基因表达的时机。随着大脑的依次发育，这些属性至关重要，单细胞空间组织会影响细胞状态，因此功能。我们的基本前提是，神经发育障碍和小儿肿瘤的根本原因是产前分化受损。与小儿脑肿瘤有关的数据，神经发育障碍,脑细胞（子）类型，地点,在发育中的大脑中表达的时机很少。然而,新兴的单细胞技术，包括转录组，空间生物学,在大脑发育时间内进行空间高分辨率成像，在破译脑病理学方面可能是转化性的，从而在药理学上。
