PDF(Pubmed)
Abstract：
Ulcerative colitis (UC) is a persistent inflammatory condition that specifically targets the colon and rectum. Existing therapies fail to adequately address the clinical requirements of people suffering from this ailment. Despite the acknowledged potential of nanomedicines in the field of anti-inflammatory treatment, their widespread use in clinical settings is impeded by their expensive nature and the uncertainty surrounding their safety profiles. This study illustrates that two naturally occurring phytochemicals, Costunolide (COS) and Glycyrrhizic acid (GA), form carrier-free, multifunctional spherical nanoparticles (NPs) through noncovalent interactions, such as π-π stacking and hydrogen bonding. The COS-GA NPs displayed a synergistic anti-inflammatory effect, providing much more evidently improved therapeutic benefits for dextran sodium sulfate (DSS)-induced UC mice due to more effective reduction in inflammation and oxidative stress than did equal dosages of COS or GA used alone. In addition, COS-GA NPs have biocompatibility and biosafety properties unique to them. This study will serve as affirmation of the potential of COS-GA NPs as innovative natural anti-inflammatory and antioxidant activities and also such agents as drug discovery in UC, leading possibly to better outcomes in people living with this disabling condition.
摘要：
溃疡性结肠炎(UC)是一种特异性靶向结肠和直肠的持续炎症状态。现有的疗法未能充分满足患有这种疾病的人的临床要求。尽管纳米药物在抗炎治疗领域具有公认的潜力，它们在临床环境中的广泛使用受到其昂贵性质和围绕其安全性的不确定性的阻碍.这项研究表明，两种天然存在的植物化学物质，Cosulide（COS）和甘草酸（GA），形成无载体，多功能球形纳米粒子（NPs）通过非共价相互作用，如π-π堆叠和氢键。COS-GANP表现出协同抗炎作用，与单独使用相等剂量的COS或GA相比，由于更有效地减少了炎症和氧化应激，为葡聚糖硫酸钠（DSS）诱导的UC小鼠提供了更明显的改善的治疗效果。此外,COS-GANP具有其独特的生物相容性和生物安全性。这项研究将肯定COS-GANP作为创新的天然抗炎和抗氧化活性以及在UC中发现药物的潜力，可能会给患有这种残疾疾病的人带来更好的结果。
