Abstract：
Nuclear factor erythroid 2-related factor 1 (NFE2L1, also known as Nrf1) is a crucial member of the CNC-bZIP subfamily of transcription factors expressed ubiquitously throughout our body. Recent findings have revealed its association with various metabolic processes, encompassing glucose, lipid, and protein metabolism. In the realm of glucose metabolism, NFE2L1 exerts regulatory control by modulating pancreatic β cells and insulin production. It also influences glucose metabolism in liver and the insulin sensitivity of adipose tissue. Regarding lipid metabolism, NFE2L1 governs this process by influencing the expression of specific adipogenic and lipolysis genes in both liver and adipose tissue. Additionally, NFE2L1 regulates specific lipids, such as cholesterol. These involvements underlie various manifestations of NFE2L1 deficiency such as adipocyte hypertrophy, inflammation, and steatohepatitis. In the realm of protein metabolism, NFE2L1 serves as a major transcription factor regulating the 26S proteasome genes expression, which dysfunction has been related with multiple diseases including neurodegenerative diseases, cancers, autoimmune conditions, etc. In this comprehensive review, we summarize the diverse roles that NFE2L1 plays in glucose, lipid, and protein metabolism, as well as its impact on diseases related to these metabolic processes.
摘要：
核因子红系2相关因子1（NFE2L1，也称为Nrf1）是在我们体内普遍表达的CNC-bZIP转录因子亚家族的重要成员。最近的发现揭示了它与各种代谢过程的关联，包括葡萄糖，脂质，和蛋白质代谢。在葡萄糖代谢领域，NFE2L1通过调节胰腺β细胞和胰岛素产生发挥调控作用。它还影响肝脏中的葡萄糖代谢和脂肪组织的胰岛素敏感性。关于脂质代谢，NFE2L1通过影响肝脏和脂肪组织中特定脂肪生成和脂解基因的表达来控制这一过程。此外,NFE2L1调节特定的脂质，比如胆固醇。这些涉及NFE2L1缺乏的各种表现，如脂肪细胞肥大，炎症,还有脂肪性肝炎.在蛋白质代谢领域，NFE2L1作为调控26S蛋白酶体基因表达的主要转录因子,这种功能障碍与包括神经退行性疾病在内的多种疾病相关，癌症,自身免疫性疾病，等。在这次全面审查中，我们总结了NFE2L1在葡萄糖中的不同作用，脂质，和蛋白质代谢，以及它对这些代谢过程相关疾病的影响。
