Abstract：
As the global population ages, the need to prolong lifespan and healthspan becomes increasingly imperative. Understanding the molecular determinants underlying cognitive resilience, together with changes during aging and the (epi)genetic factors that predispose an individual to decreased cognitive resilience, open avenues for researching novel therapies. This review provides a critical and timely appraisal of the molecular mechanisms underlying cognitive resilience, framed within a critical analysis of emerging therapeutic strategies to mitigate age-related cognitive decline. Significant insights from both animals and human subjects are discussed herein, directed either toward active pharmaceutical ingredients (drug repositioning or macromolecules), or, alternatively, advanced cellular therapies.
摘要：
随着全球人口老龄化,延长寿命和健康的需求变得越来越迫切。了解认知弹性的分子决定因素，以及衰老过程中的变化和使个体认知弹性下降的（epi）遗传因素，为研究新疗法开辟了道路。这篇综述对认知弹性的分子机制进行了关键和及时的评估，在对新兴治疗策略进行批判性分析的框架内，以减轻与年龄相关的认知能力下降。本文讨论了来自动物和人类受试者的重要见解，针对活性药物成分（药物重新定位或大分子），或者，或者，先进的细胞疗法。
