TRIM59 缺乏促进 M1 巨噬细胞活化并通过 STAT1 信号通路抑制结直肠癌。
关键词: Colorectal cancer M1 polarization Macrophage STAT1 TRIM59
Mesh : Animals STAT1 Transcription Factor / metabolism genetics Signal Transduction Macrophage Activation / genetics Tripartite Motif Proteins / metabolism genetics Mice Colorectal Neoplasms / metabolism pathology genetics Mice, Knockout Intracellular Signaling Peptides and Proteins / metabolism genetics deficiency Macrophages / metabolism Humans Mice, Inbred C57BL
来 源:
DOI:10.1038/s41598-024-66388-0
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