PDF(Pubmed)
Abstract：
The association between the triglyceride-glucose (TyG) index and impaired fasting glucose (IFG) in elderly individuals remains uncertain. Our study aimed to explore the association between the TyG index and the risk of future IFG in this population. This retrospective cohort study included 17,746 elderly individuals over 60. In this population, Cox regression models proportional to hazards, along with smooth curve fitting and cubic spline functions, were employed to examine the association between the baseline TyG index and the risk of IFG. Subgroup analyses and sensitivity were also performed to ensure the robustness of the study findings. After adjusting for covariates, a positive association between the TyG index and the risk of IFG was found (HR = 1.43, 95% CI 1.27-1.60, P < 0.0001). The likelihood of IFG rose steadily as the TyG index quartiles (from Q1 to Q4) increased, with Q4 demonstrating a 62% elevated risk compared to Q1 (adjusted HR = 1.62, 95% CI 1.37-1.90). Additionally, we found the association between TyG index and risk of IFG was a linear. Sensitivity and subgroup analyses confirmed the stability of the results. Our study observed a linear association between the TyG index and the development of IFG in elderly Chinese individuals. Recognizing this association can help clinicians identify high-risk individuals and implement targeted interventions to reduce their risk of progressing to diabetes.
摘要：
老年个体中甘油三酯-葡萄糖（TyG）指数与空腹血糖受损（IFG）之间的关联仍不确定。我们的研究旨在探讨TyG指数与该人群未来IFG风险之间的关系。这项回顾性队列研究包括17,746名60岁以上的老年人。在这个人群中,与风险成正比的Cox回归模型，以及平滑曲线拟合和三次样条函数，用于检查基线TyG指数与IFG风险之间的关联。还进行了亚组分析和敏感性以确保研究结果的稳健性。在调整协变量后，发现TyG指数与IFG风险呈正相关(HR=1.43,95%CI1.27-1.60,P<0.0001).随着TyG指数四分位数（从Q1到Q4）的增加，IFG的可能性稳步上升，与第一季度相比，第四季度显示62%的风险升高(调整后的HR=1.62，95%CI1.37-1.90)。此外,我们发现TyG指数与IFG风险呈线性关系.敏感性和亚组分析证实了结果的稳定性。我们的研究观察到中国老年人的TyG指数与IFG发展之间存在线性关联。认识到这种关联可以帮助临床医生识别高危个体，并实施有针对性的干预措施，以降低他们进展为糖尿病的风险。
