PDF(Pubmed)
Abstract：
The present study aimed to investigate the relationship between male hormones and metabolic dysfunction-associated fatty liver disease (MAFLD) in males.
Data from the Fangchenggang Area Male Health and Examination Survey (FAMHES) were used to analyze the male hormone levels between MAFLD patients and controls. Univariate and multivariate logistic regression analyses were performed to identify risk factors for MAFLD. Receiver operating characteristic curve analysis was used to assess the diagnostic performance of male hormones for MAFLD.
A total of 1578 individuals were included, with 482 individuals (30.54%) of MAFLD, including 293 (18.57%) with mild disease and 189 (11.98%) with moderate-to-severe disease. The MAFLD patients were significantly older than those without MAFLD. The LH, FSH, and SHBG levels in the MAFLD patients were significantly greater than those in the control group. Age, FSH, LH, SHBG, and estradiol were all risk factors for MAFLD. Age, FSH, and LH were risk factors for moderate-to-severe MAFLD. FSH was an independent risk factor for MAFLD and moderate-to-severe MAFLD. FSH showed an excellent diagnostic value, with an AUC of 0.992 alone and 0.996 after adjusting age.
Our findings indicate that FSH may be a potential diagnostic and predictive biomarker for MAFLD.
Data from the Fangchenggang Area Male Health and Examination Survey (FAMHES) were used to analyze the male hormone levels between MAFLD patients and controls. Univariate and multivariate logistic regression analyses were performed to identify risk factors for MAFLD. Receiver operating characteristic curve analysis was used to assess the diagnostic performance of male hormones for MAFLD.
A total of 1578 individuals were included, with 482 individuals (30.54%) of MAFLD, including 293 (18.57%) with mild disease and 189 (11.98%) with moderate-to-severe disease. The MAFLD patients were significantly older than those without MAFLD. The LH, FSH, and SHBG levels in the MAFLD patients were significantly greater than those in the control group. Age, FSH, LH, SHBG, and estradiol were all risk factors for MAFLD. Age, FSH, and LH were risk factors for moderate-to-severe MAFLD. FSH was an independent risk factor for MAFLD and moderate-to-severe MAFLD. FSH showed an excellent diagnostic value, with an AUC of 0.992 alone and 0.996 after adjusting age.
Our findings indicate that FSH may be a potential diagnostic and predictive biomarker for MAFLD.
摘要：
目的：本研究旨在探讨男性性激素与代谢功能障碍相关脂肪肝（MAFLD）的关系。
方法：采用防城港地区男性健康体检调查(FAMHES)数据，分析MAFLD患者与对照组的男性激素水平。进行单因素和多因素logistic回归分析以确定MAFLD的危险因素。受试者工作特征曲线分析用于评估男性激素对MAFLD的诊断性能。
结果：共纳入1578人，MAFLD有482人(30.54%)，包括293（18.57％）轻度疾病和189（11.98％）中度至重度疾病。MAFLD患者的年龄明显大于无MAFLD的患者。LH,FSH,MAFLD患者的SHBG水平明显高于对照组。年龄,FSH,LH,SHBG,和雌二醇均为MAFLD的危险因素。年龄,FSH,和LH是中重度MAFLD的危险因素。FSH是MAFLD和中重度MAFLD的独立危险因素。FSH具有良好的诊断价值,单独AUC为0.992，调整年龄后为0.996。
结论：我们的研究结果表明FSH可能是MAFLD的潜在诊断和预测生物标志物。
方法：采用防城港地区男性健康体检调查(FAMHES)数据，分析MAFLD患者与对照组的男性激素水平。进行单因素和多因素logistic回归分析以确定MAFLD的危险因素。受试者工作特征曲线分析用于评估男性激素对MAFLD的诊断性能。
结果：共纳入1578人，MAFLD有482人(30.54%)，包括293（18.57％）轻度疾病和189（11.98％）中度至重度疾病。MAFLD患者的年龄明显大于无MAFLD的患者。LH,FSH,MAFLD患者的SHBG水平明显高于对照组。年龄,FSH,LH,SHBG,和雌二醇均为MAFLD的危险因素。年龄,FSH,和LH是中重度MAFLD的危险因素。FSH是MAFLD和中重度MAFLD的独立危险因素。FSH具有良好的诊断价值,单独AUC为0.992，调整年龄后为0.996。
结论：我们的研究结果表明FSH可能是MAFLD的潜在诊断和预测生物标志物。
