Abstract：
Frontal fibrosing alopecia (FFA) is a primary cicatricial alopecia characterized by hairline recession, pruritus, and facial papules (FP). Various therapies are used to stabilize disease activity and induce remission. However, FP of FFA is resistant to treatment in many cases. In this review, we searched the PubMed and Google Scholar databases to screen the published literature on treatment options for FP in the context of FFA. Overall, 12 studies were included in this review. Available literature suggests a noticeable improvement in resistant-to-treatment FP in FFA patients with oral isotretinoin. The available evidence is limited and is derived from retrospective studies and case reports/series. Systemic isotretinoin can be considered a promising therapeutic regimen for treating resistant-to-treatment FP of FFA patients. However, more extensive, well-designed studies are necessary for confirmatory evidence.
摘要：
额叶纤维性脱发（FFA）是一种以发际线衰退为特征的原发性瘢痕性脱发，瘙痒,和面部丘疹（FP）。使用各种疗法来稳定疾病活动并诱导缓解。然而,FFA的FP在许多情况下对治疗具有抗性。在这次审查中,我们搜索了PubMed和GoogleScholar数据库,以筛选有关FFA背景下FP治疗方案的已发表文献.总的来说,该综述包括12项研究。现有文献表明，口服异维A酸的FFA患者对治疗的抗性FP明显改善。现有证据有限，来自回顾性研究和病例报告/系列。全身性异维A酸可以被认为是用于治疗FFA患者的抗性治疗FP的有希望的治疗方案。然而,更广泛，精心设计的研究对于确证证据是必要的。
