Abstract：
UNASSIGNED: To evaluate neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), neutrophil-to-monocyte ratio (NMR), and other hemogram-derived inflammatory parameters measured in the early second trimester and their association with the risk of gestational diabetes mellitus (GDM).
UNASSIGNED: This case-control study was conducted with 105 women with GDM and 205 healthy pregnant women, matched for maternal age at a 1:2 ratio with the cases at two regional maternity hospitals between January 2021 and August 2022. The inflammatory blood cell indices were tested in the early second trimester, and the patient\'s characteristics and the course of the pregnancy were analyzed. Logistic regression was used to determine the association between hematological parameters and the risk of GDM. Data were analyzed using SPSS, version 25.0 (SPSS, Chicago, IL).
UNASSIGNED: The final analysis included 310 pregnant women. The GDM group showed a higher pre-pregnancy BMI compared to the healthy controls (p < .01). There was no difference in NMR, PLR, and NLR between the groups (p = .63, .54, and .39, respectively). GDM was only positively associated with MLR (p = .02). After adjusting for potential confounding risk factors including maternal age, parity, and BMI, the multivariate regression analysis showed a higher level of MLR, with a cutoff point of 0.312, was independently associated with the risk of GDM (OR = 2.15, 95%CI 1.51-4.31, p = .03). However, ROC analysis showed that the AUC value of MLR was poor (0.670).
UNASSIGNED: We found that MLR, an inflammatory combined index derived from whole blood counts, may potentially serve as a predictor of GDM in the early second trimester.
UNASSIGNED: This case-control study was conducted with 105 women with GDM and 205 healthy pregnant women, matched for maternal age at a 1:2 ratio with the cases at two regional maternity hospitals between January 2021 and August 2022. The inflammatory blood cell indices were tested in the early second trimester, and the patient\'s characteristics and the course of the pregnancy were analyzed. Logistic regression was used to determine the association between hematological parameters and the risk of GDM. Data were analyzed using SPSS, version 25.0 (SPSS, Chicago, IL).
UNASSIGNED: The final analysis included 310 pregnant women. The GDM group showed a higher pre-pregnancy BMI compared to the healthy controls (p < .01). There was no difference in NMR, PLR, and NLR between the groups (p = .63, .54, and .39, respectively). GDM was only positively associated with MLR (p = .02). After adjusting for potential confounding risk factors including maternal age, parity, and BMI, the multivariate regression analysis showed a higher level of MLR, with a cutoff point of 0.312, was independently associated with the risk of GDM (OR = 2.15, 95%CI 1.51-4.31, p = .03). However, ROC analysis showed that the AUC value of MLR was poor (0.670).
UNASSIGNED: We found that MLR, an inflammatory combined index derived from whole blood counts, may potentially serve as a predictor of GDM in the early second trimester.
摘要：
■为了评估中性粒细胞与淋巴细胞的比率（NLR），血小板与淋巴细胞比率（PLR），单核细胞与淋巴细胞比率（MLR），中性粒细胞与单核细胞比率(NMR)，以及在妊娠中期早期测量的其他血象来源的炎症参数及其与妊娠期糖尿病（GDM）风险的关系。
这项病例对照研究是对105名GDM妇女和205名健康孕妇进行的，在2021年1月至2022年8月期间，与两家地区妇产医院的病例相匹配的产妇年龄为1:2。在妊娠中期早期测试了炎症血细胞指数，并对患者的特征和妊娠过程进行分析。使用Logistic回归来确定血液学参数与GDM风险之间的关联。使用SPSS对数据进行分析，版本25.0(SPSS，芝加哥,IL).
■最终分析包括310名孕妇。与健康对照组相比，GDM组显示出较高的孕前BMI（p<0.01）。NMR没有差异,PLR,以及组间的NLR(分别为p=.63、.54和.39)。GDM仅与MLR呈正相关(p=.02)。在调整了包括产妇年龄在内的潜在混杂风险因素后，奇偶校验，BMI,多元回归分析显示MLR水平较高，截止点为0.312,与GDM风险独立相关(OR=2.15,95CI1.51-4.31,p=.03).然而,ROC分析显示MLR的AUC值较差(0.670)。
■我们发现MLR,来自全血计数的炎症综合指数，可能在孕中期早期作为GDM的预测因子。
这项病例对照研究是对105名GDM妇女和205名健康孕妇进行的，在2021年1月至2022年8月期间，与两家地区妇产医院的病例相匹配的产妇年龄为1:2。在妊娠中期早期测试了炎症血细胞指数，并对患者的特征和妊娠过程进行分析。使用Logistic回归来确定血液学参数与GDM风险之间的关联。使用SPSS对数据进行分析，版本25.0(SPSS，芝加哥,IL).
■最终分析包括310名孕妇。与健康对照组相比，GDM组显示出较高的孕前BMI（p<0.01）。NMR没有差异,PLR,以及组间的NLR(分别为p=.63、.54和.39)。GDM仅与MLR呈正相关(p=.02)。在调整了包括产妇年龄在内的潜在混杂风险因素后，奇偶校验，BMI,多元回归分析显示MLR水平较高，截止点为0.312,与GDM风险独立相关(OR=2.15,95CI1.51-4.31,p=.03).然而,ROC分析显示MLR的AUC值较差(0.670)。
■我们发现MLR,来自全血计数的炎症综合指数，可能在孕中期早期作为GDM的预测因子。
