Mesh : Candida albicans / growth & development physiology Humans Gastrointestinal Tract / microbiology Candidiasis / microbiology Animals Hypoxia / metabolism Intestinal Mucosa / microbiology metabolism Mice Host-Pathogen Interactions Gastrointestinal Microbiome / physiology

来  源:   DOI:10.1016/j.chom.2024.06.006

Abstract:
Multiple host and microbial factors dictate whether Candida albicans can colonize the mammalian gastrointestinal tract. In this issue of Cell Host & Microbe, Savage et al. demonstrate that restoration of intestinal epithelial hypoxia is sufficient to restore Candida albicans colonization resistance, even when other Candida inhibitory effectors remain depleted.
摘要:
多种宿主和微生物因素决定了白色念珠菌是否可以在哺乳动物胃肠道定殖。在本期《细胞宿主和微生物》中,Savage等人。证明肠上皮缺氧的恢复足以恢复白色念珠菌定植抗性,即使其他念珠菌抑制效应物仍然耗尽。
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