关键词: Antisaccadic task Basal ganglia disorders Cognitive control Inhibition Oculomotor behaviour

来  源:   DOI:10.1016/j.cortex.2024.06.005

Abstract:
This review explores the role of the antisaccadic task in understanding inhibitory mechanisms in basal ganglia disorders. It conducts a comparative analysis of saccadic profiles in conditions such as Parkinson\'s disease, Tourette syndrome, obsessive-compulsive disorder, Huntington\'s disease, and dystonia, revealing distinct patterns and proposing mechanisms for impaired performance. The primary focus is on two inhibitory mechanisms: global, pre-emptive inhibition responsible for suppressing prepotent responses, and slower, selective response inhibition. The antisaccadic task demonstrates practicality in clinical applications, aiding in differential diagnoses, treatment monitoring and reflecting gait control. To further enhance its differential diagnostic value, future directions should address issues such as the standardization of eye-tracking protocol and the integration of eye-tracking data with other disease indicators in a comprehensive dataset.
摘要:
这篇综述探讨了反扫视任务在理解基底神经节疾病的抑制机制中的作用。它对帕金森病、Tourette综合征,强迫症,亨廷顿病,和肌张力障碍,揭示不同的模式,并提出绩效受损的机制。主要关注两种抑制机制:全球,先发制人的抑制负责抑制先发制人的反应,更慢,选择性反应抑制。反扫视任务证明了临床应用的实用性,帮助鉴别诊断,治疗监测和反映步态控制。进一步提高其鉴别诊断价值,未来的方向应解决诸如眼动追踪协议的标准化以及眼动追踪数据与其他疾病指标在综合数据集中的整合等问题.
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