Abstract：
Impulsivity is a trait associated with several psychiatric conditions, not least addictive disorders. While the neural mechanisms behind certain aspects of impulsivity have been studied extensively, there are few imaging studies examining this neurocircuitry in populations with substance use disorders. Therefore, we aimed to examine the functional connectivity of relevant neural networks, and their possible association with trait impulsivity, in a sample with severe amphetamine use disorder and a control group of healthy subjects. We used data collected in a randomized clinical trial studying the acute effects of oral naltrexone in amphetamine use disorder. Our final sample included 32 amphetamine users and 27 healthy controls. Trait impulsivity was rated with the Barratt Impulsiveness Scale-11, and functional connectivity was measured during resting-state fMRI, looking specifically at networks involving prefrontal regions previously implicated in studies of impulsivity. Amphetamine users had higher subjective ratings of impulsivity as compared to healthy controls, and these scores correlated positively with a wide-spread prefrontal hyperconnectivity that was found among the amphetamine users. These findings highlight the importance of aberrant prefrontal function in severe addiction.
摘要：
冲动性是与几种精神疾病相关的特征，尤其是成瘾性疾病。虽然冲动性某些方面背后的神经机制已经被广泛研究，很少有影像学研究在有物质使用障碍的人群中检查这种神经回路。因此,我们旨在研究相关神经网络的功能连通性，以及它们与特质冲动的可能联系，在患有严重安非他明使用障碍的样本和健康受试者的对照组中。我们使用了一项随机临床试验中收集的数据，研究了口服纳曲酮对苯丙胺使用障碍的急性影响。我们的最终样本包括32名苯丙胺使用者和27名健康对照。用Barratt冲动性量表11对特质冲动进行评估，并在静息状态fMRI期间测量功能连通性，专门研究以前涉及冲动性研究的涉及前额叶区域的网络。与健康对照组相比，安非他明使用者对冲动性的主观评分更高，这些分数与苯丙胺使用者中广泛存在的前额叶高度连通性呈正相关.这些发现强调了严重成瘾中前额叶功能异常的重要性。
