关键词: Mycetoma Nocardia mexicana tropical disease

Mesh : Humans Male Adult Nocardia / isolation & purification genetics Mycetoma / microbiology drug therapy diagnosis Nocardia Infections / microbiology drug therapy diagnosis Forearm / microbiology pathology Thorax / diagnostic imaging microbiology Neck / pathology Anti-Bacterial Agents / therapeutic use RNA, Ribosomal, 16S / genetics Sequence Analysis, DNA DNA, Bacterial / genetics Treatment Outcome Trimethoprim, Sulfamethoxazole Drug Combination / therapeutic use Amikacin / therapeutic use DNA, Ribosomal / genetics chemistry

来  源:   DOI:10.3855/jidc.18182

Abstract:
BACKGROUND: Mycetoma is a chronic granulomatous inflammatory disease of the subcutaneous tissue, which affects deep structures and bone. Most cases of actinomycetoma are caused by members of the genus Nocardia.
METHODS: Here we report the case of a 43-year-old male who presented a disseminated mycetoma on the forearm, chest and neck, characterized by enlarged and erythematous lesions through which seropurulent material drains, and numerous atrophic scars. Molecular identification was performed by 16S gene amplification and sequencing. Nocardia mexicana was identified with 100% identity. Trimethoprim-sulfamethoxazole, diaminodiphenyl sulfone and amikacin was a successful treatment after 6 months.
CONCLUSIONS: Nocardia mexicana is a rare organism that causes mycetoma. We report a case of extensive mycetoma on the forearm with spread to the neck and thorax associated with manipulation of the mouth of a calf.
摘要:
背景:Mycetoma是一种皮下组织的慢性肉芽肿性炎症性疾病,影响深层结构和骨骼。大多数放线菌瘤是由诺卡氏菌属成员引起的。
方法:这里我们报道了一个43岁男性前臂上出现播散性肌瘤的病例,胸部和颈部,以肥大和红斑性病变为特征,血清脓性物质通过该病变排出,和许多萎缩性疤痕。通过16S基因扩增和测序进行分子鉴定。墨西哥诺卡氏菌被鉴定为100%的同一性。甲氧苄啶-磺胺甲恶唑,二氨基二苯砜和阿米卡星是6个月后成功的治疗方法。
结论:墨西哥诺卡氏菌是一种罕见的细菌,可引起肌瘤。我们报告了一例前臂广泛的肌瘤,并与小腿嘴的操纵有关,扩散到颈部和胸部。
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