PDF(Pubmed)
Abstract：
Cancer is the leading cause of death worldwide, and the number of cancer-related deaths is expected to increase. Common types of cancer include skin, breast, lung, prostate, and colorectal cancers. While clinical research has improved cancer therapies, these treatments often come with significant side effects such as chronic fatigue, hair loss, and nausea. In addition, cancer treatments can cause long-term cardiovascular complications. Doxorubicin (DOX) therapy is one example, which can lead to decreased left ventricle (LV) echocardiography (ECHO) parameters, increased oxidative stress in cellular level, and even cardiac fibrosis. The apelinergic system, specifically apelin and its receptor, together, has shown properties that could potentially protect the heart and mitigate the damages caused by DOX anti-cancer treatment. Studies have suggested that stimulating the apelinergic system may have therapeutic benefits for heart damage induced by DOX. Further research in chronic preclinical models is needed to confirm this hypothesis and understand the mechanism of action for the apelinergic system. This review aims to collect and present data on the effects of the apelinergic system on doxorubicin-induced cardiotoxicity.
摘要：
癌症是全世界死亡的主要原因,与癌症相关的死亡人数预计会增加。常见的癌症类型包括皮肤癌，乳房,肺，前列腺,和大肠癌。虽然临床研究改善了癌症治疗，这些治疗通常会带来严重的副作用，例如慢性疲劳，脱发,和恶心。此外,癌症治疗可引起长期心血管并发症。阿霉素（DOX）治疗是一个例子，这可能导致左心室（LV）超声心动图（ECHO）参数降低，细胞水平的氧化应激增加，甚至心脏纤维化。apelinine能系统,特别是apelin及其受体，一起,已显示出可能保护心脏并减轻DOX抗癌治疗造成的损害的特性。研究表明，刺激apelinine能系统可能对DOX引起的心脏损伤具有治疗作用。需要对慢性临床前模型进行进一步研究以证实这一假设并了解apelinine能系统的作用机制。这篇综述旨在收集和提供有关apelinine能系统对阿霉素诱导的心脏毒性的影响的数据。
