PDF(Pubmed)
Abstract：
Atherosclerosis (AS) is the main pathological basis of cardiovascular diseases such as coronary heart disease. Black phosphorus quantum dots (BPQDs) are a novel nanomaterial with good optical properties and biocompatibility, which was applied in the treatment of AS in mice, with good results shown in our previous study. In this study, BPQDs were injected into high-fat diet-fed apolipoprotein E knockout mice as a preventive drug for 12 weeks. Simvastatin, a classic preventive drug for AS, was used as a control to verify the preventive effect of BPQDs. The results showed that after preventive treatment with BPQDs, the plaque area in mice was significantly reduced, the vascular elasticity was increased, and serum lipid levels were significantly lower than those in the model group. To explore the mechanism, macrophages were induced to become foam cells using oxidized low-density lipoprotein. We found that BPQDs treatment could increase cell autophagy, thereby regulating intracellular lipid metabolism. Taken together, these data revealed that BPQDs may serve as a functional drug in preventing the development of AS.
摘要：
动脉粥样硬化(AS)是冠心病等心血管疾病的主要病理基础。黑磷量子点(BPQDs)是一种具有良好光学性能和生物相容性的新型纳米材料,应用于小鼠AS的治疗，在我们之前的研究中显示了良好的结果。在这项研究中,将BPQDs注射到高脂饮食喂养的载脂蛋白E基因敲除小鼠中作为预防药物，持续12周。辛伐他汀,一种典型的预防AS的药物，作为对照，验证BPQDs的预防效果。结果表明，在使用BPQDs进行预防性治疗后，小鼠的斑块面积显著减少，血管弹性增加，和血脂水平显著低于模型组。为了探索机制，使用氧化低密度脂蛋白诱导巨噬细胞成为泡沫细胞。我们发现BPQDs治疗可以增加细胞自噬，从而调节细胞内脂质代谢。一起来看,这些数据表明，BPQDs可能作为预防AS发展的功能性药物。
