Abstract：
In recent years, there has been a growing interest in multifunctional theranostic agents capable of delivering therapeutic payloads while facilitating simultaneous diagnostic imaging of diseased sites. This approach offers a comprehensive strategy particularly valuable in dynamically evolving diseases like cancer, where combining therapy and diagnostics provides crucial insights for treatment planning. Nanoscale platforms, specifically nanogels, have emerged as promising candidates due to their stability, tunability, and multifunctionality as carriers. As a well-studied subgroup of soft polymeric nanoparticles, nanogels exhibit inherent advantages due to their size and chemical compositions, allowing for passive and active targeting of diseased tissues. Moreover, nanogels loaded with therapeutic and diagnostic agents can be designed to respond to specific stimuli at the disease site, enhancing their efficacy and specificity. This capability enables fine-tuning of theranostic platforms, garnering significant clinical interest as they can be tailored for personalized treatments. The ability to monitor tumor progression in response to treatment facilitates the adaptation of therapies according to individual patient responses, highlighting the importance of designing theranostic platforms to guide clinicians in making informed treatment decisions. Consequently, the integration of therapy and diagnostics using theranostic platforms continues to advance, offering intelligent solutions to address the challenges of complex diseases such as cancer. In this context, nanogels capable of delivering therapeutic payloads and simultaneously armed with diagnostic modalities have emerged as an attractive theranostic platform. This review focuses on advances made toward the fabrication and utilization of theranostic nanogels by highlighting examples from recent literature where their performances through a combination of therapeutic agents and imaging methods have been evaluated.
摘要：
近年来,人们对多功能治疗诊断药物的兴趣与日俱增,所述治疗诊断药物能够递送治疗有效负荷,同时促进疾病部位的同时诊断成像.这种方法提供了一个全面的策略，特别有价值的动态发展的疾病，如癌症，结合治疗和诊断为治疗计划提供了至关重要的见解。纳米级平台,特别是纳米凝胶，由于他们的稳定性而成为有前途的候选人，可调谐性，和作为载体的多功能性。作为一个经过充分研究的软聚合物纳米粒子亚组，纳米凝胶由于其尺寸和化学组成而表现出固有的优势，允许被动和主动靶向病变组织。此外，装载有治疗和诊断剂的纳米凝胶可以被设计为对疾病部位的特定刺激做出反应，增强其功效和特异性。此功能可实现对theranostic平台的微调，获得显著的临床兴趣，因为它们可以为个性化治疗量身定制。响应于治疗监测肿瘤进展的能力有助于根据个体患者的反应来适应治疗。强调设计治疗平台以指导临床医生做出明智的治疗决策的重要性。因此,使用theranostic平台的治疗和诊断的整合继续推进，提供智能解决方案，以应对癌症等复杂疾病的挑战。在这种情况下，能够提供治疗有效载荷并同时配备诊断模式的纳米凝胶已成为有吸引力的治疗平台。这篇综述通过突出最近文献中的例子，重点介绍了在治疗性纳米凝胶的制造和利用方面取得的进展，其中通过治疗剂和成像方法的组合评估了它们的性能。
