关键词: Liposomes ethosomes niosomes sphingosomes transferosomes

Mesh : Liposomes / chemistry Drug Carriers / chemistry Humans Drug Delivery Systems Animals

来  源:   DOI:10.1080/02652048.2024.2376116

Abstract:
UNASSIGNED: There are around 24 distinct lipid vesicles described in the literature that are similar to vesicular systems such as liposomes. Liposome-like structures are formed by combining certain amphiphilic lipids with a suitable stabiliser. Since their discovery and classification, self-assembled liposome-like structures as active drug delivery vehicles captured researchers\' curiosity.
UNASSIGNED: This comprehensive study included an in-depth literature search using electronic databases such as PubMed, ScienceDirect and Google Scholar, focusing on studies on liposome and liposomes like structure, discussed in literature till 2024, their sizes, benefits, drawback, method of preparation, characterisation and pharmaceutical applications.
UNASSIGNED: Pharmacosomes, cubosomes, ethosomes, transethosomes, and genosomes, all liposome-like structures, have the most potential due to their smaller size with high loading capacity, ease of absorption, and ability to treat inflammatory illnesses. Genosomes are futuristic because of its affinity for DNA/gene transport, which is an area of focus in today\'s treatments.
UNASSIGNED: This review will critically analyse the composition, preparation procedures, drug encapsulating technologies, drug loading, release mechanism, and related applications of all liposome-like structures, highlighting their potential benefits with enhanced efficacy over each other and over traditional carriers by paving the way for exploring novel drug delivery systems in the Pharma industry.
摘要:
文献中描述了约24种不同的脂质囊泡,其类似于囊泡系统如脂质体。脂质体样结构通过将某些两亲性脂质与合适的稳定剂组合而形成。自从他们的发现和分类以来,自组装的脂质体样结构作为活性药物递送载体引起了研究人员的好奇心。
这项综合研究包括使用PubMed等电子数据库进行深入的文献检索,科学直接和谷歌学者,重点研究脂质体和脂质体样结构,直到2024年在文献中讨论,它们的大小,好处,缺点,制备方法,表征和药物应用。
药物组,立方体,乙醇体,跨丝小体,和基因组,所有的脂质体样结构,具有最大的潜力,因为它们具有较小的尺寸和高的承载能力,易于吸收,和治疗炎症性疾病的能力。基因组是未来的,因为它对DNA/基因运输的亲和力,这是当今治疗的重点领域。
这篇评论将批判性地分析其组成,准备程序,药物封装技术,药物装载,释放机构,以及所有脂质体样结构的相关应用,通过为在制药行业中探索新型药物输送系统铺平道路,强调它们的潜在益处,增强彼此之间和传统载体的功效。
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