Abstract：
UNASSIGNED: To investigate the genetic contribution of 24 GWAS-associated polymorphic gene variants on the development of children\'s B-lineage acute lymphoblastic leukemia (B-ALL) in an ethnically homogeneous population of Kazakhs.
UNASSIGNED: A study of 205 children with B-ALL and 204 healthy children was conducted. Genotyping of polymorphic loci was carried out using the TaqMan method.
UNASSIGNED: Significant associations (p < 0.05) with the risk of childhood B-ALL were found for twelve variants, including rs6457327 of the HLA gene, rs4251961 of the IL1RN gene, and rs1800630 of the TNF gene. Carriage of the minor allele A of the protective rs1801157 polymorphism A of the CXCL12 gene reduces the risk of B-ALL in the Kazakh population by 40%.
UNASSIGNED: The results reveal significant associations of polymorphic genetic variants, which can serve as a basis for the development of effective methods for predicting the risk of B-ALL, early diagnosis, and timely treatment.
UNASSIGNED: A study of 205 children with B-ALL and 204 healthy children was conducted. Genotyping of polymorphic loci was carried out using the TaqMan method.
UNASSIGNED: Significant associations (p < 0.05) with the risk of childhood B-ALL were found for twelve variants, including rs6457327 of the HLA gene, rs4251961 of the IL1RN gene, and rs1800630 of the TNF gene. Carriage of the minor allele A of the protective rs1801157 polymorphism A of the CXCL12 gene reduces the risk of B-ALL in the Kazakh population by 40%.
UNASSIGNED: The results reveal significant associations of polymorphic genetic variants, which can serve as a basis for the development of effective methods for predicting the risk of B-ALL, early diagnosis, and timely treatment.
摘要：
■研究24个GWAS相关多态性基因变异对哈萨克人种族同质人群儿童B系急性淋巴细胞白血病（B-ALL）发展的遗传贡献。
■对205名B-ALL儿童和204名健康儿童进行了研究。使用TaqMan方法进行多态位点的基因分型。
■发现12种变异与儿童B-ALL风险显著相关（p<0.05），包括HLA基因的rs6457327，IL1RN基因的rs4251961，和TNF基因的rs1800630。携带CXCL12基因的保护性rs1801157多态性A的次要等位基因A可将哈萨克族人群中B-ALL的风险降低40％。
■结果显示多态遗传变异的显著关联，这可以作为开发预测B-ALL风险的有效方法的基础，早期诊断,及时治疗。
■对205名B-ALL儿童和204名健康儿童进行了研究。使用TaqMan方法进行多态位点的基因分型。
■发现12种变异与儿童B-ALL风险显著相关（p<0.05），包括HLA基因的rs6457327，IL1RN基因的rs4251961，和TNF基因的rs1800630。携带CXCL12基因的保护性rs1801157多态性A的次要等位基因A可将哈萨克族人群中B-ALL的风险降低40％。
■结果显示多态遗传变异的显著关联，这可以作为开发预测B-ALL风险的有效方法的基础，早期诊断,及时治疗。
