Abstract：
Patients with chronic pancreatitis are at risk of developing malabsorption and malnutrition. Exocrine pancreatic insufficiency is accompanied by decreased serum micronutrient levels and low vitamin D levels are a frequent finding in up to 60-80% of patients. The aim of our prospective study was to investigate vitamin D in the blood serum of subjects with chronic pancreatitis with the possibility of influencing the reduced vitamin D levels with supplementation therapy.
METHODS: Fifty patients with chronic pancreatitis and 20 subjects in the control group without gastrointestinal tract diseases, including pancreatic disease, were examined. The vitamin D level in blood serum was determined. The results were evaluated according to the age distribution of subjects with pancreatic disease and according to gender. Patients with low vitamin D levels were treated for 24 weeks with a dose of 1.500.000 IU of vitamin D3 per day, and then blood serum vitamin D levels were determined.
RESULTS: In people with chronic pancreatitis, vitamin D levels were statistically significantly reduced compared to the control group. There was no statistically significant relationship of vitamin D with gender and age. Supplementation with vitamin D3 achieved an adjustment of vitamin D level to the level of the control group.
CONCLUSIONS: Blood serum vitamin D levels are significantly reduced in people with chronic pancreatitis. Its correction by oral vitamin D supplementation was effective. Whether this adjustment of levels will be effective also in terms of e.g. beneficial effect on fibrogenesis will require further representative studies, because the limitation of the interpretation of the results of our study is the smaller number of subjects with chronic pancreatitis (Tab. 4, Ref. 29).
METHODS: Fifty patients with chronic pancreatitis and 20 subjects in the control group without gastrointestinal tract diseases, including pancreatic disease, were examined. The vitamin D level in blood serum was determined. The results were evaluated according to the age distribution of subjects with pancreatic disease and according to gender. Patients with low vitamin D levels were treated for 24 weeks with a dose of 1.500.000 IU of vitamin D3 per day, and then blood serum vitamin D levels were determined.
RESULTS: In people with chronic pancreatitis, vitamin D levels were statistically significantly reduced compared to the control group. There was no statistically significant relationship of vitamin D with gender and age. Supplementation with vitamin D3 achieved an adjustment of vitamin D level to the level of the control group.
CONCLUSIONS: Blood serum vitamin D levels are significantly reduced in people with chronic pancreatitis. Its correction by oral vitamin D supplementation was effective. Whether this adjustment of levels will be effective also in terms of e.g. beneficial effect on fibrogenesis will require further representative studies, because the limitation of the interpretation of the results of our study is the smaller number of subjects with chronic pancreatitis (Tab. 4, Ref. 29).
摘要：
慢性胰腺炎患者有发生吸收不良和营养不良的风险。胰腺外分泌功能不全伴随着血清微量营养素水平的降低,在高达60-80%的患者中经常发现低维生素D水平。我们前瞻性研究的目的是调查慢性胰腺炎患者血清中的维生素D，并通过补充治疗影响维生素D水平降低的可能性。
方法：慢性胰腺炎患者50例，无胃肠道疾病的对照组20例，包括胰腺疾病,进行了检查。测定血清中维生素D水平。根据胰腺疾病患者的年龄分布和性别对结果进行评估。维生素D水平低的患者接受了24周的治疗，每天服用1.500.000IU的维生素D3，然后测定血清维生素D水平。
结果：在慢性胰腺炎患者中，与对照组相比，维生素D水平在统计学上显著降低。维生素D与性别、年龄的关系无统计学意义。补充维生素D3可将维生素D水平调整到对照组的水平。
结论：慢性胰腺炎患者血清维生素D水平显著降低。通过口服补充维生素D对其进行校正是有效的。这种水平的调整是否在例如对纤维发生的有益作用方面也是有效的，需要进一步的代表性研究。因为我们研究结果解释的局限性在于慢性胰腺炎的受试者数量较少（Tab.4，参考。29).
方法：慢性胰腺炎患者50例，无胃肠道疾病的对照组20例，包括胰腺疾病,进行了检查。测定血清中维生素D水平。根据胰腺疾病患者的年龄分布和性别对结果进行评估。维生素D水平低的患者接受了24周的治疗，每天服用1.500.000IU的维生素D3，然后测定血清维生素D水平。
结果：在慢性胰腺炎患者中，与对照组相比，维生素D水平在统计学上显著降低。维生素D与性别、年龄的关系无统计学意义。补充维生素D3可将维生素D水平调整到对照组的水平。
结论：慢性胰腺炎患者血清维生素D水平显著降低。通过口服补充维生素D对其进行校正是有效的。这种水平的调整是否在例如对纤维发生的有益作用方面也是有效的，需要进一步的代表性研究。因为我们研究结果解释的局限性在于慢性胰腺炎的受试者数量较少（Tab.4，参考。29).
