Abstract：
Particulate matter (PM) imposes a significant impact to environmental health with deleterious effects on the human pulmonary and cardiovascular systems. Macrophages (Mφ), key immune cells in lung tissues, have a prominent role in responding to inhaled cells, accommodating inflammation, and influencing tissue repair processes. Elucidating the critical cellular responses of Mφ to PM exposure is essential to understand the mechanisms underlying PM-induced health effects. The present review aims to give a glimpse on literature about the PM interaction with Mφ, triggering the cellular events causing the inflammation, oxidative stress (OS) and tissue damage. The present paper reviews the different pathways involved in Mφ activation upon PM exposure, including phagocytosis, intracellular signaling cascades, and the release of pro-inflammatory mediators. Potential therapeutic strategies targeting Mφ-mediated responses to reduce PM-induced health effects are also discussed. Overall, unraveling the complex interplay between PM and Mφ sheds light on new avenues for environmental health research and promises to develop targeted interventions to reduce the burden of PM-related diseases on global health.
摘要：
颗粒物（PM）对环境健康产生重大影响，对人体肺部和心血管系统产生有害影响。巨噬细胞（Mφ），肺组织中的关键免疫细胞，在对吸入细胞的反应中起着重要作用，调节炎症，影响组织修复过程。阐明Mφ对PM暴露的关键细胞反应对于了解PM引起的健康影响的潜在机制至关重要。本综述旨在简要介绍有关PM与Mφ相互作用的文献，引发引起炎症的细胞事件，氧化应激(OS)和组织损伤。本文综述了PM暴露时Mφ活化的不同途径，包括吞噬作用,细胞内信号级联，和促炎介质的释放。还讨论了针对Mφ介导的反应以减少PM引起的健康影响的潜在治疗策略。总的来说,揭示PM和Mφ之间复杂的相互作用为环境健康研究提供了新的途径，并有望制定有针对性的干预措施，以减轻PM相关疾病对全球健康的负担。
