PDF(Pubmed)
Abstract：
UNASSIGNED: Tissues\' biomechanical properties, such as elasticity, are related to tissue health. Optical coherence elastography produces images of tissues based on their elasticity, but its performance is constrained by the laser power used, working distance, and excitation methods.
UNASSIGNED: We develop a new method to reconstruct the elasticity contrast image over a long working distance, with only low-intensity illumination, and by non-contact acoustic wave excitation.
UNASSIGNED: We combine single-photon vibrometry and quantum parametric mode sorting (QPMS) to measure the oscillating backscattered signals at a single-photon level and derive the phantoms\' relative elasticity.
UNASSIGNED: We test our system on tissue-mimicking phantoms consisting of contrast sections with different concentrations and thus stiffness. Our results show that as the driving acoustic frequency is swept, the phantoms\' vibrational responses are mapped onto the photon-counting histograms from which their mechanical properties-including elasticity-can be derived. Through lateral and longitudinal laser scanning at a fixed frequency, a contrast image based on samples\' elasticity can be reliably reconstructed upon photon level signals.
UNASSIGNED: We demonstrated the reliability of QPMS-based elasticity contrast imaging of agar phantoms in a long working distance, low-intensity environment. This technique has the potential for in-depth images of real biological tissue and provides a new approach to elastography research and applications.
UNASSIGNED: We develop a new method to reconstruct the elasticity contrast image over a long working distance, with only low-intensity illumination, and by non-contact acoustic wave excitation.
UNASSIGNED: We combine single-photon vibrometry and quantum parametric mode sorting (QPMS) to measure the oscillating backscattered signals at a single-photon level and derive the phantoms\' relative elasticity.
UNASSIGNED: We test our system on tissue-mimicking phantoms consisting of contrast sections with different concentrations and thus stiffness. Our results show that as the driving acoustic frequency is swept, the phantoms\' vibrational responses are mapped onto the photon-counting histograms from which their mechanical properties-including elasticity-can be derived. Through lateral and longitudinal laser scanning at a fixed frequency, a contrast image based on samples\' elasticity can be reliably reconstructed upon photon level signals.
UNASSIGNED: We demonstrated the reliability of QPMS-based elasticity contrast imaging of agar phantoms in a long working distance, low-intensity environment. This technique has the potential for in-depth images of real biological tissue and provides a new approach to elastography research and applications.
摘要：
■组织生物力学特性，比如弹性，与组织健康有关。光学相干弹性成像根据组织的弹性产生图像，但是它的性能受到所用激光功率的限制，工作距离,和激励方法。
■我们开发了一种新方法来重建长工作距离的弹性对比图像，只有低强度的照明，并通过非接触声波激励。
■我们将单光子测振法和量子参数模式分类（QPMS）结合起来，以测量单光子水平的振荡反向散射信号，并得出幻像\'相对弹性。
■我们在由不同浓度和因此硬度的对比切片组成的组织模拟体模上测试了我们的系统。我们的结果表明，随着驱动声频率的扫描，体模的振动响应被映射到光子计数直方图上，从中可以得出它们的机械性能，包括弹性。通过固定频率的横向和纵向激光扫描，基于样本弹性的对比图像可以根据光子水平信号可靠地重建。
■我们证明了在长工作距离内基于QPMS的琼脂体模弹性对比成像的可靠性，低强度环境。该技术具有用于真实生物组织的深度图像的潜力，并为弹性成像研究和应用提供了新的方法。
■我们开发了一种新方法来重建长工作距离的弹性对比图像，只有低强度的照明，并通过非接触声波激励。
■我们将单光子测振法和量子参数模式分类（QPMS）结合起来，以测量单光子水平的振荡反向散射信号，并得出幻像\'相对弹性。
■我们在由不同浓度和因此硬度的对比切片组成的组织模拟体模上测试了我们的系统。我们的结果表明，随着驱动声频率的扫描，体模的振动响应被映射到光子计数直方图上，从中可以得出它们的机械性能，包括弹性。通过固定频率的横向和纵向激光扫描，基于样本弹性的对比图像可以根据光子水平信号可靠地重建。
■我们证明了在长工作距离内基于QPMS的琼脂体模弹性对比成像的可靠性，低强度环境。该技术具有用于真实生物组织的深度图像的潜力，并为弹性成像研究和应用提供了新的方法。
