PDF(Pubmed)
Abstract：
UNASSIGNED: Colorectal cancer (CRC), a leading global malignancy, continues to challenge the medical community. Despite advancements in surgical, chemotherapeutic, radiation, targeted, and immunotherapeutic strategies, issues like resistance and side effects persist. This review illuminates the potential of ferroptosis, an emerging non-apoptotic cell death form, and graphene oxide (GO), with its distinctive physicochemical properties, in CRC therapy.
UNASSIGNED: The databases search included PubMed, Medline and Web of Science. Search terms focused on CRC, graphene, GO, ferroptosis, and related aspects in therapy and drug delivery. The time frame for literature retrieval was up to April 2024. Studies in languages other than English were excluded.
UNASSIGNED: Ferroptosis has been recognized for its role in addressing treatment resistance, a notable hurdle in effective CRC management. This form of cell death offers a promising avenue for enhancing the effectiveness of existing treatments. However, understanding its mechanisms and clinical implications in CRC remains an area of active research, with significant progress required for its practical application. Simultaneously, GO, a versatile two-dimensional material, has demonstrated substantial potential in biomedical applications, especially in cancer therapy. Its high specific surface area and unique π-electron domains facilitate the effective binding of chemotherapy drugs, target genes, and photosensitizers. This makes GO a promising candidate in cancer diagnosis and treatment, particularly through tumor photothermal and photodynamic therapy (PDT). Despite these advancements, GO\'s clinical application faces challenges, including in vitro cytotoxicity and decreased biodegradability, necessitating further research.
UNASSIGNED: This review focuses on the characteristics of GO and ferroptosis, as well as their applications in tumor diagnosis and treatment, with a particular emphasis on their potential in CRC.
UNASSIGNED: The databases search included PubMed, Medline and Web of Science. Search terms focused on CRC, graphene, GO, ferroptosis, and related aspects in therapy and drug delivery. The time frame for literature retrieval was up to April 2024. Studies in languages other than English were excluded.
UNASSIGNED: Ferroptosis has been recognized for its role in addressing treatment resistance, a notable hurdle in effective CRC management. This form of cell death offers a promising avenue for enhancing the effectiveness of existing treatments. However, understanding its mechanisms and clinical implications in CRC remains an area of active research, with significant progress required for its practical application. Simultaneously, GO, a versatile two-dimensional material, has demonstrated substantial potential in biomedical applications, especially in cancer therapy. Its high specific surface area and unique π-electron domains facilitate the effective binding of chemotherapy drugs, target genes, and photosensitizers. This makes GO a promising candidate in cancer diagnosis and treatment, particularly through tumor photothermal and photodynamic therapy (PDT). Despite these advancements, GO\'s clinical application faces challenges, including in vitro cytotoxicity and decreased biodegradability, necessitating further research.
UNASSIGNED: This review focuses on the characteristics of GO and ferroptosis, as well as their applications in tumor diagnosis and treatment, with a particular emphasis on their potential in CRC.
摘要：
■结直肠癌（CRC），全球领先的恶性肿瘤，继续挑战医学界。尽管外科手术取得了进展，化疗，辐射,有针对性的,和免疫治疗策略，阻力和副作用等问题仍然存在。这篇综述阐明了铁中毒的潜力，一种新兴的非凋亡性细胞死亡形式，和氧化石墨烯（GO），以其独特的物理化学性质，在CRC治疗中。
■数据库搜索包括PubMed，Medline和WebofScience。搜索词集中在CRC上，石墨烯,石墨烯GO,铁性凋亡,以及治疗和药物递送的相关方面。文献检索的时间范围为2024年4月。英语以外的语言研究被排除在外。
■Ferroptosis因其在解决治疗耐药性方面的作用而得到认可，有效的CRC管理中的一个显著障碍。这种形式的细胞死亡为增强现有治疗的有效性提供了有希望的途径。然而,了解其在CRC中的机制和临床意义仍然是一个活跃的研究领域，其实际应用需要取得重大进展。同时,GO,一种多功能的二维材料，在生物医学应用中显示出巨大的潜力，特别是在癌症治疗中。其高比表面积和独特的π电子域有助于化疗药物的有效结合，靶基因,和光敏剂。这使得GO成为癌症诊断和治疗的有希望的候选者，特别是通过肿瘤光热和光动力疗法（PDT）。尽管取得了这些进步,GO的临床应用面临挑战，包括体外细胞毒性和生物降解性降低，需要进一步研究。
■这篇综述集中在GO和铁性的特征上，以及它们在肿瘤诊断和治疗中的应用，特别强调他们在CRC中的潜力。
■数据库搜索包括PubMed，Medline和WebofScience。搜索词集中在CRC上，石墨烯,石墨烯GO,铁性凋亡,以及治疗和药物递送的相关方面。文献检索的时间范围为2024年4月。英语以外的语言研究被排除在外。
■Ferroptosis因其在解决治疗耐药性方面的作用而得到认可，有效的CRC管理中的一个显著障碍。这种形式的细胞死亡为增强现有治疗的有效性提供了有希望的途径。然而,了解其在CRC中的机制和临床意义仍然是一个活跃的研究领域，其实际应用需要取得重大进展。同时,GO,一种多功能的二维材料，在生物医学应用中显示出巨大的潜力，特别是在癌症治疗中。其高比表面积和独特的π电子域有助于化疗药物的有效结合，靶基因,和光敏剂。这使得GO成为癌症诊断和治疗的有希望的候选者，特别是通过肿瘤光热和光动力疗法（PDT）。尽管取得了这些进步,GO的临床应用面临挑战，包括体外细胞毒性和生物降解性降低，需要进一步研究。
■这篇综述集中在GO和铁性的特征上，以及它们在肿瘤诊断和治疗中的应用，特别强调他们在CRC中的潜力。
