PDF(Pubmed)
Abstract：
UNASSIGNED: Matrix metalloproteinase 11 (MMP11) plays a vital role in cell proliferation, apoptosis, tumor angiogenesis, migration, and other basic processes. Currently, few studies have examined the value of MMP11 in pancreatic cancer in relation to prognostic risk, diagnostic indicators, and immunotherapy. This study aims to explore the association between MMP11 and the tumor immune microenvironment in pancreatic adenocarcinoma (PAAD).
UNASSIGNED: We selected clinical samples and data downloaded from The Cancer Genome Atlas and Genotype-Tissue Expression, in addition, we use other online data for further analysis. Through a comprehensive bioinformatics investigation, we systematically analyzed the clinical significance and expression level of MMP11 in pancreatic cancer.
UNASSIGNED: MMP11 was overexpressed in many cancers, and a higher expression of MMP11 was associated with a poorer prognosis in pancreatic cancer. Conversely, the hypermethylation of MMP11 was associated with better overall survival. The MMP11 expression network had widespread effects on the prognosis and immune activation of PAAD. The expression of MMP11 was significantly associated with a variety of tumor-infiltrating immune cells. An association was also found between MMP11 expression and chemokines in PAAD. High MMP11 expression might be involved in immune cell migration to the tumor microenvironment.
UNASSIGNED: MMP11 is a prognostic biomarker for patients in pancreatic cancer and may regulate the tumor immune microenvironment. The potential effects and mechanisms of MMP11 in PAAD require further exploring.
UNASSIGNED: We selected clinical samples and data downloaded from The Cancer Genome Atlas and Genotype-Tissue Expression, in addition, we use other online data for further analysis. Through a comprehensive bioinformatics investigation, we systematically analyzed the clinical significance and expression level of MMP11 in pancreatic cancer.
UNASSIGNED: MMP11 was overexpressed in many cancers, and a higher expression of MMP11 was associated with a poorer prognosis in pancreatic cancer. Conversely, the hypermethylation of MMP11 was associated with better overall survival. The MMP11 expression network had widespread effects on the prognosis and immune activation of PAAD. The expression of MMP11 was significantly associated with a variety of tumor-infiltrating immune cells. An association was also found between MMP11 expression and chemokines in PAAD. High MMP11 expression might be involved in immune cell migration to the tumor microenvironment.
UNASSIGNED: MMP11 is a prognostic biomarker for patients in pancreatic cancer and may regulate the tumor immune microenvironment. The potential effects and mechanisms of MMP11 in PAAD require further exploring.
摘要：
■基质金属蛋白酶11（MMP11）在细胞增殖中起着至关重要的作用，凋亡，肿瘤血管生成,迁移,和其他基本过程。目前,很少有研究检查MMP11在胰腺癌预后风险中的价值，诊断指标,和免疫疗法。本研究旨在探讨MMP11与胰腺癌(PAAD)肿瘤免疫微环境的关系。
■我们选择了从癌症基因组图谱和基因型组织表达下载的临床样本和数据，此外,我们使用其他在线数据进行进一步分析。通过全面的生物信息学调查，系统分析MMP11在胰腺癌中的表达水平及临床意义。
■MMP11在许多癌症中过度表达，MMP11的高表达与胰腺癌预后较差相关。相反，MMP11的高甲基化与更好的总生存期相关.MMP11表达网络对PAAD的预后和免疫激活有广泛的影响。MMP11的表达与多种肿瘤浸润免疫细胞显著相关。在PAAD中MMP11表达和趋化因子之间也发现了关联。MMP11的高表达可能与免疫细胞向肿瘤微环境的迁移有关。
■MMP11是胰腺癌患者的预后生物标志物，可能调节肿瘤免疫微环境。MMP11在PAAD中的潜在作用及机制有待进一步探讨。
■我们选择了从癌症基因组图谱和基因型组织表达下载的临床样本和数据，此外,我们使用其他在线数据进行进一步分析。通过全面的生物信息学调查，系统分析MMP11在胰腺癌中的表达水平及临床意义。
■MMP11在许多癌症中过度表达，MMP11的高表达与胰腺癌预后较差相关。相反，MMP11的高甲基化与更好的总生存期相关.MMP11表达网络对PAAD的预后和免疫激活有广泛的影响。MMP11的表达与多种肿瘤浸润免疫细胞显著相关。在PAAD中MMP11表达和趋化因子之间也发现了关联。MMP11的高表达可能与免疫细胞向肿瘤微环境的迁移有关。
■MMP11是胰腺癌患者的预后生物标志物，可能调节肿瘤免疫微环境。MMP11在PAAD中的潜在作用及机制有待进一步探讨。
