PDF(Pubmed)
Abstract：
UNASSIGNED: Lactic acid is a metabolite of glycolysis produced in the body, and its production is thought to be a mechanism by which cancer cells evade immune surveillance. Immune evasion and metabolic changes are well established as basic hallmarks of cancer. Although lactate has long been considered a waste product, it is now generally recognized to be a versatile small-molecule chemical that plays an important part in the tumor microenvironment (TME), with increased lactate production linked to the development of human malignancies. Metabolism in liver cancer is redirected toward glycolysis, which enhances the production of metabolic compounds used by tumor cells to produce proteins, lipids, and nucleotides, enabling them to maintain high proliferation rates and to establish the TME. Dysregulation of metabolic activity in liver cancer may impair antitumor responses owing to the immunosuppressive activity of the lactate produced by anaerobic glycolytic rates in tumor cells. This review primarily explores the link connection between lactic acid and the TME; evaluates the role of lactic acid in the occurrence, metastasis, prognosis, and treatment of liver cancer. Additionally, it investigates the associated pathways as potential targets for liver cancer treatment.
UNASSIGNED: Literature searches were conducted in PubMed, Web of Science, and Google Scholar, with the publication date of the most recent article included being January 2024. After eliminating duplicate articles and less relevant articles through titles and abstracts, we selected 113 articles for this review. We categorized references into two categories. One is to classify the content into lactate-related, liver cancer-related and tumor metabolism-related. The other is to classify the article types, which are divided into reviews, research articles and clinical trials. Additionally, we consulted the reference lists of the relevant articles to ensure coverage was comprehensive and unbiased.
UNASSIGNED: The connection between lactic acid and the TME has recently become an area of intense research interest, and many related articles have been published in this field. The main finding of this review is to summarize the proven link between lactate and the TME and its possible impact on the TME of liver cancer. And analyzed the potential of lactate in liver cancer treatment and prognosis prediction.
UNASSIGNED: Lactate may be key to developing novel approaches in the future treatment of liver cancer. Related research on the combination of classic therapies and molecular targeted drugs may provide innovative medicines that more selectively regulate immune cell activity.
UNASSIGNED: Literature searches were conducted in PubMed, Web of Science, and Google Scholar, with the publication date of the most recent article included being January 2024. After eliminating duplicate articles and less relevant articles through titles and abstracts, we selected 113 articles for this review. We categorized references into two categories. One is to classify the content into lactate-related, liver cancer-related and tumor metabolism-related. The other is to classify the article types, which are divided into reviews, research articles and clinical trials. Additionally, we consulted the reference lists of the relevant articles to ensure coverage was comprehensive and unbiased.
UNASSIGNED: The connection between lactic acid and the TME has recently become an area of intense research interest, and many related articles have been published in this field. The main finding of this review is to summarize the proven link between lactate and the TME and its possible impact on the TME of liver cancer. And analyzed the potential of lactate in liver cancer treatment and prognosis prediction.
UNASSIGNED: Lactate may be key to developing novel approaches in the future treatment of liver cancer. Related research on the combination of classic therapies and molecular targeted drugs may provide innovative medicines that more selectively regulate immune cell activity.
摘要：
■乳酸是体内产生的糖酵解的代谢产物，它的产生被认为是癌细胞逃避免疫监视的一种机制。免疫逃避和代谢变化是癌症的基本标志。虽然乳酸一直被认为是废物，它现在被公认为是一种多功能的小分子化学物质，在肿瘤微环境（TME）中起着重要作用，乳酸产量增加与人类恶性肿瘤的发展有关。肝癌的代谢转向糖酵解，这增强了肿瘤细胞用来生产蛋白质的代谢化合物的产生，脂质，和核苷酸，使它们能够保持高的增殖率并建立TME。由于肿瘤细胞中厌氧糖酵解速率产生的乳酸的免疫抑制活性，肝癌中代谢活性的失调可能会损害抗肿瘤反应。这篇综述主要探讨了乳酸与TME之间的联系；评估了乳酸在TME发生中的作用，转移,预后,和肝癌的治疗。此外,它研究了相关的途径作为肝癌治疗的潜在目标。
■文献检索在PubMed中进行，WebofScience,和谷歌学者，最近一篇文章的发表日期为2024年1月。在通过标题和摘要消除重复的文章和不太相关的文章之后，我们选择了113篇文章进行这篇评论。我们将参考文献分为两类。一种是将含量分为与乳酸相关的，肝癌相关和肿瘤代谢相关。另一种是对文章类型进行分类，分为评论，研究文章和临床试验。此外,我们查阅了相关文章的参考清单，以确保报道全面和公正。
■乳酸与TME之间的联系最近已成为一个备受关注的研究领域，和许多相关的文章已经发表在这一领域。这篇综述的主要发现是总结乳酸与TME之间的已证实的联系及其对肝癌TME的可能影响。并分析乳酸在肝癌治疗及预后预测中的潜力。
■乳酸可能是开发未来肝癌治疗新方法的关键。经典疗法与分子靶向药物结合的相关研究可能提供更具选择性地调节免疫细胞活性的创新药物。
■文献检索在PubMed中进行，WebofScience,和谷歌学者，最近一篇文章的发表日期为2024年1月。在通过标题和摘要消除重复的文章和不太相关的文章之后，我们选择了113篇文章进行这篇评论。我们将参考文献分为两类。一种是将含量分为与乳酸相关的，肝癌相关和肿瘤代谢相关。另一种是对文章类型进行分类，分为评论，研究文章和临床试验。此外,我们查阅了相关文章的参考清单，以确保报道全面和公正。
■乳酸与TME之间的联系最近已成为一个备受关注的研究领域，和许多相关的文章已经发表在这一领域。这篇综述的主要发现是总结乳酸与TME之间的已证实的联系及其对肝癌TME的可能影响。并分析乳酸在肝癌治疗及预后预测中的潜力。
■乳酸可能是开发未来肝癌治疗新方法的关键。经典疗法与分子靶向药物结合的相关研究可能提供更具选择性地调节免疫细胞活性的创新药物。
