PDF(Pubmed)
Abstract：
Comprehension of the typical distribution pattern of 99mTc-methylenediphosphonate (MDP) is crucial for precise interpretation of bone scintigraphy. The presence of nonskeletal activity is predominantly confined to the kidneys and bladder, attributed to the standard renal excretion of 99mTc-MDP. We discuss a 70-year-old woman with a known case of brucellosis using rifampin, doxycycline, trimethoprim/sulfamethoxazole (co-trimoxazole), and ciprofloxacin for the past 8 months. Anterior and posterior aspects of the whole-body bone scan showed diffuse increased uptake in the bodies of L2 and L3 vertebrae and related intervertebral disks. However, unexpected uptake is noted in the right upper quadrant in the region of the gallbladder. Radiochemical impurities did not show during radiopharmaceutical (MDP) quality control, and the other patients showed normal distribution. This gallbladder uptake may be attributed to the altered distribution of the radiotracer and/or gallbladder injury caused by the administration of antibiotic therapy.
摘要：
了解99mTc-亚甲基二膦酸盐（MDP）的典型分布模式对于精确解释骨闪烁显像至关重要。非骨骼活动的存在主要局限于肾脏和膀胱，归因于99mTc-MDP的标准肾脏排泄。我们讨论了一名70岁的妇女，她患有利福平的布鲁氏菌病，多西环素,甲氧苄啶/磺胺甲恶唑（复方新诺明），和环丙沙星在过去8个月.全身骨扫描的前后方面显示，L2和L3椎骨以及相关椎间盘的吸收增加。然而,在胆囊区域的右上象限注意到意外的摄取。在放射性药物（MDP）质量控制期间未显示放射性化学杂质，其他患者呈正态分布。这种胆囊摄取可归因于由施用抗生素治疗引起的放射性示踪剂和/或胆囊损伤的改变的分布。
